Sclerostin is a protein that in humans is encoded by the SOST gene. [5] It is a secreted glycoprotein with a C-terminal cysteine knot -like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

2024年12月25日 · SOST (Sclerostin) is a Protein Coding gene. Diseases associated with SOST include Sclerosteosis 1 and Craniodiaphyseal Dysplasia, Autosomal Dominant. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by …

硬化蛋白(Sclerostin, SOST)主要由骨细胞特异性表达, 是骨形成的负性调节因子。甲状旁腺激素和雌激素抑制SOST基因表达, 转录因子Osterix、Runx2和Mef2c促进SOST基因表达, 而转录因子Sirt1负调控SOST表达。此外, SOST基因表达还受DNA甲基化和microRNA等表观遗传学调控。

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder ...

Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling.

Sclerostin, the product of the SOST gene, is a secreted inhibitor of Wnt signaling that is produced by osteocytes to regulate bone formation. While it is often considered an osteocyte-specific protein, SOST expression has been reported in numerous other cell types, including hypertrophic chondrocytes and cementocytes.

SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone homeostasis. The objective of this work was to assess the functionality of ...

2024年11月27日 · Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

硬化蛋白是一种分泌型糖蛋白，具有 C 末端半胱氨酸结样 (CTCK) 结构域和与骨形态发生蛋白 (BMP) 拮抗剂 DAN (神经母细胞瘤中的差异筛选选择基因异常) 家族的序列相似性。 该基因的功能丧失突变与常染色体隐性遗传病、硬化症有关，它会导致进行性骨过度生长。 该基因下游的缺失导致硬化蛋白表达减少，与一种称为 van Buchem 病的较温和的疾病有关。 [RefSeq 提供，2008 年 …

2001年6月1日 · Heterozygous mutations located in the secretion signal of the SOST gene prevent sclerostin secretion and can be responsible for craniodiaphyseal dysplasia. A severe bone dysplasia characterized by massive generalized hyperostosis and sclerosis, especially involving the skull and facial bones.