2001年10月23日 · Some loading regimens involve giving either 600 mg per day for 4 weeks (123) or greater than or equal to 1 g per day for 1 week (124) followed by lower maintenance doses. Quinidine, procainamide, and disopyramide should generally not be started out of hospital.

2024年2月26日 · Intravenous loading of sotalol is recommended to facilitate the initiation of oral sotalol therapy. Sotalol is also used as an off-label medication for pharmacological cardioversion of atrial fibrillation, premature ventricular contractions, postoperative atrial fibrillation after cardiac surgery, and supraventricular tachycardia (SVT).

The DASH-AF (Feasibility and Safety of Intravenous Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy in Adult Patients With Atrial Fibrillation) trial evaluates the safety and feasibility of intravenous (IV) sotalol, achieving a steady state with maximum QTc prolongation within 6 hours instead of the traditional 5-dose ...

This novel IV sotalol load could decrease the length of hospital admission, decrease overall admission cost, and improve patient satisfaction. We describe the first use of a single-dose IV sotalol load with an outpatient observation period to …

2024年2月26日 · Loading of oral sotalol for atrial fibrillation requires 3 days, frequently in the hospital, to achieve steady state. The Food and Drug Administration approved loading with intravenous (IV) sotalol through model-informed development, without patient data. We present results of the first multicenter evaluation of this recent labeling for IV sotalol.

2025年2月1日 · Rapid intravenous (IV) sotalol loading over 60 minutes for atrial arrhythmias achieves the maximum plasma concentration (Cmax) steady state in <24 hours in patients with creatinine clearance > 60 mL/min as compared with ≥72 hours with oral sotalol loading, resulting in a decreased length of stay.

2023年4月1日 · DASH-AF demonstrates that rapid loading of sotalol using an IV starter regimen is feasible and safe compared with the conventional oral loading protocols. Repolarization changes as assessed by change in QTc interval was numerically lower with IV sotalol loading, thus possibly resulting in less dose adjustment than the conventional PO dosing ...

Oral sotalol is commonly used for rhythm control in patients with recurrent symptomatic atrial fibrillation (AF). The drug is usually initiated in the hospital for the first 5 doses, resulting in a 3-day inpatient stay to monitor for excessive QT prolongation, bradycardia, and …

The aim of this study is to develop an intravenous to oral loading regime for sotalol therapy that reduces the 3-day in-hospital initiation or dose escalation with oral administration to 1 day without compromising patient safety.

The FDA approved loading with intravenous (IV) sotalol through model-informed development, without patient data. We present results of the first, multicenter, prospective evaluation of this recent labeling for IV sotalol, and including pharmacokinetics/pharmacodynamics (PK/PD) profiles and mobile ECG monitoring.