2024年12月25日 · SOX17 (SRY-Box Transcription Factor 17) is a Protein Coding gene. Diseases associated with SOX17 include Vesicoureteral Reflux 3 and Familial Vesicoureteral Reflux. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by WNT.

2024年2月28日 · We propose that SOX17 is a transcription factor that is engaged during the early steps of colon cancer to orchestrate an immune-evasive programme that permits CRC initiation and progression.

SOX17 is involved in the regulation of vertebrate embryonic development and in the determination of the endodermal cell fate. The encoded protein acts downstream of TGF beta signaling (Activin) and canonical WNT signaling (Wnt3a).

2024年3月17日 · 这项研究的细节发表在《Nature》杂志上的一篇题为“SOX17 enables immune evasion of early colorectal adenomas and cancers”的论文中。 这项研究仍处于早期阶段，但它可能会带来一种针对SOX17途径的新疗法的发展。

2025年2月8日 · Sox17 prominently contributes to gastric cancer progression through regulating proliferation and cell cycle, indicating a novel diagnosis and prognosis biomarker as well as a potential therapeutic target in gastric cancer; SOX17 negatively regulates canonical WNT/beta-catenin signaling pathway and inhibits human HCC cells growth

SOX17是一种特殊的转录因子，其在结肠癌发生早期阶段能参与调解免疫逃逸程序从而允许结直肠癌的发生和进展。 免疫 系统的主要作用之一就是检测并杀灭已经获得致癌突变的细胞，然而，一些早期阶段的 癌细胞 会设法躲避这种监视并进展为更晚期的肿瘤。 近日，一篇发表在国际杂志Nature上题为“SOX17 enables immune evasion of early colorectal adenomas and cancers”的研究报告中，来自麻省理工学院等机构的科学家们通过研究识别出了一种能帮助这些癌前细胞躲避 …

2019年5月9日 · Here we show that the endothelial and hematopoietic developmental transcription factor Sox17 promotes endothelial regeneration in the endotoxemia model of endothelial injury. Genetic lineage...

sox17 已通过基因研究与肺动脉高压 (pah) 相关联，体内模型已证明其在肺血管发育中的关键作用。 SOX17 基因示意图，表明在肺动脉高压患者中通过测序鉴定的变异

2015年1月15日 · Remarkably, SOX17 is the key regulator of hPGC-like fate, whereas BLIMP1 represses endodermal and other somatic genes during specification of hPGCLCs. Notable mechanistic differences between mouse and human PGC specification could be attributed to their divergent embryonic development and pluripotent states, which might affect other early cell ...

2024年2月28日 · Precancerous colon cells can avoid immune detection by turning on a gene called SOX17, which allows them to become essentially invisible to the immune system, an MIT study finds.