Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene. [5][6][7] This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of …

2024年12月25日 · SOX4 (SRY-Box Transcription Factor 4) is a Protein Coding gene. Diseases associated with SOX4 include Intellectual Developmental Disorder With Speech Delay And …

SOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ …

2020年12月1日 · In this review, we summarize the current state of knowledge about the role of SOX4 in cancer development and progression, the epigenetic regulation of SOX4, and the …

2024年2月26日 · In lineage-traced cells, we assessed the timing of SOX4-mediated opening of enhancer chromatin versus enhancer decommissioning. Initially, SOX4 directly binds to and …

SOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ …

2012年7月1日 · Here we investigated the role of Sox4 in peripheral CD4 + T cells and found that Sox4 was a downstream target of the TGF-β signaling pathway that negatively regulated T H 2 …

2021年4月9日 · Here we demonstrate that the transcription factor SOX4 is a key regulator of PI3K signaling in TNBC. Genomic and proteomic analyses coupled with mechanistic studies …

Our results suggest that SOX4 is a target TGF-β signaling and mediates TGF-β-induced EMT and stem cell characteristics of GC cells, revealing a novel role of TGF-β/SOX4 axis in the …

2013年6月10日 · Gene expression profiling has uncovered the transcription factor Sox4 with upregulated activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal …