2016年10月1日 · Calcitonin gene related peptide (CGRP) and substance P (SP) are neuropeptides that are simultaneously released from nociceptive C-fibers. CGRP is a potent vasodilator, inducing a long-lasting increase in superficial skin blood flow, whereas SP induces only a brief vasodilation but a significant plasma extravasation.

CGRP作为促炎剂能够急活肥大细胞、巨噬细胞、黑素细胞、树突细胞和淋巴B细胞、T细胞，促进由IL-1和IL-8诱导的水肿发展，并且对中性粒细胞具有趋化性。CGRP与SP具有协同作用，SP可诱导CGRP释放，CGRP增强SP的作用。 3. 血管活性长肽(vasoactive intestinal peptide，VIP)

神经肽p物质(sp)和降钙素基因相关肽(cgrp)是感觉神经末梢释放的重要疼痛介质，同时参与机体的骨代谢活动。 我们前期工作证实SP,CGRP在退行性骨关节疾病患者松质骨内的表达和疼痛程度有密切关系，提示神经肽可能在骨质疏松性疼痛中发挥了作用，但SP,CGRP对于 ...

Substance P (SP) and calcitonin gene-related peptide (CGRP) are two sensory neuropeptides that have been associated with regulation of osteogenic differentiation. However, the interaction between SP and CGRP both with each other and the bone morphogenetic protein 2 (BMP2) in regulation of osteogenic differentiation has not been studied.

Calcitonin gene related peptide (CGRP) and substance P (SP) are neuropeptides that are simultaneously released from nociceptive C-fibers. CGRP is a potent vasodilator, inducing a long-lasting increase in superficial skin blood flow, whereas SP induces only a brief vasodilation but a significant plas …

SP acting on NK 1 receptors is a potent mediator of increased microvascular permeability and, as extensively discussed, CGRP is an extremely potent vasodilator, thus release of these peptides results in edema formation, increased blood flow, and recruitment of …

Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia. Experimental models have demonstrated that nitroglycerin (NTG)--a nitric oxide donor--provokes a hyperalgesic state, probably via the activation of second-order neurons in …

Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in ...

2024年9月11日 · 此外，cgrp 和 sp 的作用可以在共培养模型中使用各自的拮抗剂进行分析，或者通过直接添加到 ec 单一培养物上进行分析。 我们发现辣椒素刺激的 SN 会诱导 EC 中 Ca2+

2013年11月4日 · 本实验通过对 IBS 患者及正常人结肠黏膜活检标本的放射免疫测定及免疫组织化学研究，探讨胃肠激素 P 物质 （substance P， SP）、 血管活性肠肽 （ vasoac-tive intestinai poiypeptide， VIP）、 降 钙 素 基 因 相 关 肽（caiciionin gene-reiated peptide， CGRP） 在 IBS …