Sphingolipid - Wikipedia
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature.
Sphingolipid – Definition, Structure, Types, Functions
2024年4月1日 · Some of the key functions of sphingolipids include: Cell Signaling: Sphingolipids act as crucial mediators of cellular signaling pathways. Ceramides, in particular, play a significant role in regulating cell growth, differentiation, and apoptosis (programmed cell death).
Sphingolipids and their metabolism in physiology and disease
2017年11月22日 · Taken together, these studies begin to define several causal roles for sphingolipids in normal brain functions and as mediators of neuronal damage and neurodegenerative disorders.
Sphingolipid - an overview | ScienceDirect Topics
Sphingolipids are a class of lipids characterised by the presence of a sphingosine backbone. This includes a range of lipids including ceramide, sphingosine and sphingomyelin. A range of different cellular functions for sphingolipids have been described. Sphingolipids are a key structural component for membranes, including lipid rafts [57].
Functional roles of sphingolipids in immunity and their …
2023年6月1日 · In this review, we analyze sphingolipid-related enzymes and reported human diseases to understand the important roles of sphingolipid metabolism. We discuss the defects and alterations in...
Regulation of cellular and systemic sphingolipid homeostasis
2024年6月18日 · Sphingolipids are a heterogeneous group of lipids with important roles in membrane form and function, cell signalling, and development.
Sphingolipid Metabolic Pathway: An Overview of Major Roles …
Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in diverse functions controlling fundamental cellular processes such as cell division, differentiation, and cell death.
Diverse Biological Functions of Sphingolipids in the CNS: …
Sphingolipids are enriched in the Central Nervous System (CNS) and display multiple biological functions. They participate in tissue development, cell recognition and adhesion, and act as receptors for toxins.
1.5: Sphingolipids - Physics LibreTexts
There are many biological functions associated with sphingolipids, including cellular regulation, signaling and metabolism. Biophysical Properties Sphingolipids tend to form clustered structured called microdomains, rafts, or caveolae (when containing caveolin).
An overview of sphingolipid metabolism: from synthesis to …
Sphingolipids are a diverse group of lipids which serve a variety of functions in both mammalian development and physiology. Only a few of these functions have been highlighted in the chapter, but the scope of sphingolipid biology is vast.