2024年12月25日 · Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in T cell receptor signaling pathway; membrane protein proteolysis; and positive regulation of calcineurin-NFAT signaling cascade.

2024年12月25日 · This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like …

2024年12月25日 · SPPL2B (Signal Peptide Peptidase Like 2B) is a Protein Coding gene. Diseases associated with SPPL2B include Cerebral Amyloid Angiopathy, Itm2b-Related, 1 and Cerebral Amyloid Angiopathy, Itm2b-Related, 2. Among its related pathways are TNF signaling and p75 NTR receptor-mediated signalling.

Signal peptide peptidase-like 2 (SPPL) proteases constitute a subfamily of SPP/SPPL intramembrane proteases which are homologues of the presenilins, the catalytic core of the γ-secretase complex. The three SPPL2 proteases SPPL2a, SPPL2b and SPPL2c proteolyse single-span, type II-oriented transmembra …

2023年10月3日 · Recently, the artificial intelligence-based structure prediction tool AlphaFold has added high-confidence models of the expected fold of SPP/SPPL proteases. In this review, we summarize known structural aspects of the SPP/SPPL family as well as their substrates.

Signal peptide peptidase (SPP) and the four SPP-like proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 constitute a family of aspartyl intramembrane proteases with homology to presenilins. The different members reside in distinct cellular localisations within the secretory pathway and the endo-lysosomal system.

Signal peptide peptidase (SPP) and the homologous SPP-like (SPPL) proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 belong to the family of GxGD intramembrane proteases. SPP/SPPLs selectively cleave transmembrane domains in type II orientation and do not require additional co-factors for proteolytic activi …

In the present review, we will summarise our state of knowledge on SPP/SPPL proteases and in particular highlight recently iden-tified substrates and the functional and/or (patho)-physiological implications of these cleavage events. Based on this, we aim to provide an overview of the current open questions in the field.

2023年8月25日 · Signal peptide peptidase (SPP) and the four SPP-like proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 constitute a family of aspartyl intramembrane proteases with homology to presenilins. The different members reside in distinct cellular localisations within the secretory pathway and the endo-lysosomal system.

2024年12月25日 · SPPL2C (Signal Peptide Peptidase Like 2C) is a Protein Coding gene. Diseases associated with SPPL2C include Combined Oxidative Phosphorylation Deficiency 21 and Chromosome 17Q21.31 Duplication Syndrome. Among its related pathways is 11p11.2 copy number variation syndrome.