This study investigates 1) the anticancer efficacy of a new squalenoyl prodrug of gemcitabine (SQgem) in nanoassembly form compared with gemcitabine at equitoxic doses and 2) the subacute and acute preclinical toxicity of these compounds.

2008年5月1日 · This study investigates 1) the anticancer efficacy of a new squalenoyl prodrug of gemcitabine (SQgem) in nanoassembly form compared with gemcitabine at equitoxic doses and 2) the subacute and acute preclinical toxicity of these compounds.

2017年5月30日 · Here we show that nanoparticles made of the squalene derivative of gemcitabine (SQGem) interact with lipoproteins (LPs), indirectly enabling the targeting of cancer cells with high LP receptors...

2021年11月20日 · Nanoparticles (NPs) made of the squalene–gemcitabine (SQGem) conjugate were found to have a high affinity for plasma lipoproteins while free gemcitabine did not, suggesting a key role of the lipid moiety in this event.

2023年2月1日 · SQGem accumulates in the plasma membranes with disrupted lipid asymmetry. SQGem is taken up selectively by malignant cells. SQGem is more toxic to cancer cells in comparison to their benign counterparts.

2018年9月5日 · Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with the squalenoylated gemcitabine (SqGem) conjugate are cumbers …

2017年5月30日 · Here we show that nanoparticles made of the squalene derivative of gemcitabine (SQGem) interact with lipoproteins (LPs), indirectly enabling the targeting of cancer cells with high LP receptors expression.

2008年2月4日 · In this study, the dynamically folded conformation of squalene (SQ) is taken advantage of to link this natural compound to the anticancer nucleoside analogue gemcitabine (gem) in order to achieve the spontaneous formation of nanoassemblies (SQgem) in water.

2008年6月1日 · This study investigates 1) the anticancer efficacy of a new squalenoyl prodrug of gemcitabine (SQgem) in nanoassembly form compared with gemcitabine at equitoxic doses and 2) the subacute and...

2017年7月5日 · The proof of concept of this approach has been achieved by the chemical linkage of the anticancer drug gemcitabine (Gem) to squalene (SQ; a natural lipid precursor of the cholesterol’s biosynthesis), which additionally triggers the self-assembly of the SQ-drug bioconjugates into nanoparticles (SQGem NPs). 34 The conjugation to SQ has also ...