自噬学习三------SQSTM1/p62 知多少？ - 简书
2020年3月3日 · SQSTM1/p62在清除泛素化蛋白中起着重要作用，它同时调节核转录相关因子2-抗氧化反应元件、NF-κB 和胱天蛋白酶8 介导的凋亡等信号通路；SQSTM1/p62的异常表达与神 …
SQSTM1 Gene - GeneCards | SQSTM Protein | SQSTM Antibody
2024年12月25日 · SQSTM1 (Sequestosome 1) is a Protein Coding gene. Diseases associated with SQSTM1 include Paget Disease Of Bone 3 and Frontotemporal Dementia And/Or …
SQSTM1/p62 (SQSTM1)靶点介绍及实验小贴士| Abcam中文官网
SQSTM1/p62是与泛素结合的适配器蛋白，可能参与调节TNF-alpha、神经生长因子 (NGF)和白细胞介素-1对NFKB1的 激活。 可能参与肌细胞肌动蛋白/TTN下游信号转导。 可能通过泛素化调 …
Sequestosome 1 - Wikipedia
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5][6][7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that …
一个挑起自噬与凋亡大梁的蛋白p62 - 搜狐
2017年9月18日 · P62是众所周知的自噬蛋白，也称为SQSTM1蛋白，可在肿瘤细胞中发挥自噬与凋亡的作用。 包括4个结构域，分别是PB1，TB，LIR，UBA。 其中LIR结构域负责与自噬受 …
SQSTM1 sequestosome 1 [ Homo sapiens (human) ] - National …
2025年2月8日 · PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein …
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in …
In this review, we highlight recent advances in understanding the role of p62 in coordinating the ubiquitin-proteasome system and autophagy. We also discuss positive and negative effects of …
SQSTM1/p62: A Potential Target for Neurodegenerative Disease
2019年5月15日 · SQSTM1/p62 is a scaffold protein closely involved in the macroautophagy process. p62 functions to anchor the ubiquitinated proteins to the autophagosome membrane, …
p62/SQSTM1-droplet serves as a platform for autophagosome
2021年1月4日 · In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62 …
sequestosome 1（SQSTM1）基因 | MCE
该基因编码一种多功能蛋白，可结合泛素并调节核因子 kappa-B (NF-kB) 信号通路的激活。 该蛋白质作为支架/衔接蛋白与 TNF 受体相关因子 6 协同作用，以响应上游信号介导 NF-kB 的激活 …