Squamous cell carcinoma is characterized by: Scaly, rough skin patches; Firm, red nodules; Open sores, including those that develop within scars; Marks that look like age spots; Growths that look like warts or have a horn-like appearance ; These symptoms of skin cancer on the legs are things to look for.

Background: Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE). Objective: We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs.

Skin cancer on the leg typically appears as a small raised bump or a dark spot with uneven borders. However, its appearance can vary between individuals depending on a number of factors.

This crusty spot near the eye was diagnosed as a squamous cell carcinoma (SCC). A wart-like growth that crusts and occasionally bleeds. This horn-shaped growth on the lower eyelid, known as a cutaneous horn, is an SCC.

Lower extremity squamous cell carcinomas usually affect the anterior aspect of the lower limb and occur mostly in women and black individuals [3,4]. The incidence of nodule metastasis from SCC of the skin is approximately 4-5%, and 1.5% of individuals die from this disease [ 5 , 6 ].