2024年12月25日 · SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1) is a Protein Coding gene. Diseases associated with SREBF1 include Ifap Syndrome 2 and Mucoepithelial Dysplasia, Hereditary. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism of steroids.

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.

人类表达两种不同的SREBP，称为固醇调节元件结合转录因子1（SREBF1）和SREBF2。哺乳动物的SREBF1有两种转录本， SREBP-1a 和 SREBP-1c （也称为adipocyte differentiation-1，ADD1）。人的SREBP-1a在脾脏和肠道中占主导地位，而在肝脏、脂肪组织和骨骼肌中以SREBP-1c为主。

2023年11月5日 · Our study demonstrates that SREBF1 controls the balance of lipid synthesis, uptake, storage and liberation to maintain lipid homeostasis for rapid tumor growth, while suggesting it as a very promising molecular target for cancer treatment.

2025年2月23日 · We constructed a risk score based on SREBF1 target genes associated with the biochemical recurrence of prostate cancer by combining bulk RNA analysis. Finally, we verified the effects of the...

Gene ID: 6720, updated on 19-Feb-2025. This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis.

2023年12月11日 · SREBF1通过调节下游靶点（FASN、ACLY和SCD1）并抑制ROS诱导的铁死亡，重新编程了胰腺癌的脂肪酸代谢。因此，SREBF1抑制剂fatostatin通过诱导铁死亡显著降低了高表达BHLHE40的胰腺癌肿瘤的生长。 BHLHE40沉默可减少. 胰腺癌肿瘤发生和转移. 03

该基因编码一个基本的螺旋-环-螺旋-亮氨酸拉链 (bHLH-Zip) 转录因子，它与甾醇调节元件 1 (SRE1) 结合，后者是在低密度脂蛋白受体基因启动子中发现的基序和其他参与甾醇生物合成的基因。 编码的蛋白质作为前体合成，最初附着在核膜和内质网上。 切割后，成熟蛋白易位至细胞核并激活转录。 这种裂解被甾醇抑制。 该基因位于 17 号染色体上的 Smith-Magenis 综合征区域内。 替代启动子的使用和剪接导致多个转录变体，包括 SREBP-1a 和 SREBP-1c，它们分别对应 …

2025年1月4日 · Title: A gain-of-function variant in SREBF1 causes generalized skin hyperpigmentation with congenital cataracts. FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1.

2025年2月8日 · Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression. The involvement of SREBP-1c in FASN promoter histone modification. Data show that TO901317 increased expression of both Liver X receptors (LXRalpha and LXRbeta) isoforms and its target genes: sterol response element binding protein 1c (SREBP-1c) and acetyl ...