Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in …

2024年3月30日 · Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appropriate SRY expression to initiate testis-determination in humans.

2015年12月16日 · Twenty-five years ago, Sinclair et al. 1 reported in Nature that TDF was the gene SRY. This discovery opened up the surprisingly intricate genetic pathway that determines whether a baby is born a...

SRY基因，雄性的性别决定基因，指Y染色体上具体决定生物雄性性别的基因片段。人的SRY基因位于Yp11.3，只含有一个外显子，没有内含子，转录单位长约1.1kb，编码一个204氨基酸的蛋白质。

sry-box 转录因子 5： 该基因编码参与胚胎发育调控和细胞命运决定的转录因子 sox (sry 相关 hmg 盒) 家族成员。 编码的蛋白质在与其他蛋白质形成蛋白质复合物后可以充当转录调节剂。

2024年12月25日 · SOX5 (SRY-Box Transcription Factor 5) is a Protein Coding gene. Diseases associated with SOX5 include Lamb-Shaffer Syndrome and Large Congenital Melanocytic Nevus. Among its related pathways are Endochondral ossification …

2024年3月30日 · Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appropriate SRY expression to initiate testis-determination in humans.

2010年12月1日 · SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation.

除了染色体组成外，部分的单个基因也会决定人类的性别表现，其中最重要的性别决定基因即为——sry。 SRY基因 位于Y染色体p11.2区域，该基因编码一个转录调控因子，决定着男性性别发育的起始。

Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SOX5 (SRY-box transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]