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Tropomyosin receptor kinase A (TrkA), [5] also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

TRKA receptors are involved in pain sensation; loss-of-function mutations in TRKA are observed in class IV hereditary sensory and autonomic neuronal disorders (such as congenital insensitivity to pain with anhidrosis), which result in impaired ability to …

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. [1][2] Trk receptors affect neuronal survival and differentiation through several signaling cascades. However, the activation of these receptors also has significant effects on functional properties of neurons.

2010年2月1日 · TrkA is a receptor tyrosine kinase able to activate multiple downstream second-messenger signaling cascades and promote nociceptor excitability via sensitization of several ion channels, including TRPV1, ASIC3, P2X3, and NaV.

2021年2月1日 · TRKs can regulate cell proliferation, differentiation and even apoptosis through the RAS/MAPKs, PI3K/AKT and PLCγ pathways. Gene fusions involving NTRK act as oncogenic drivers of a broad diversity of adult and pediatric tumors, and TRKs have become promising antitumor targets.

The p75 ICD –TrkA (or c29–TrkA) active complex binds NGF through high-affinity ECD sites. Allosteric modulation to the Trk ECD may (i) improve ligand access to D5, (ii) position D1 and D4 appropriately to promote ligand-D5 interaction, and/or (iii) reveal a second NGF-binding site.

Based on our previous findings on synthetic dehydroepiandrosterone derivatives, we identified a novel NGF mimetic, named ENT-A013, which selectively activates TrkA and exerts neuroprotective, anti-amyloid-β actions.

1996年6月1日 · 我们通过免疫组织化学方法研究了高亲和力神经营养蛋白受体TrkA，TrkB和TrkC在成年人的正常非神经元组织中的分布。 除心脏和肝脏外，在所有检查的组织中均检测到Trk免疫反应性（IR）。

2022年12月12日 · 目的观察电针“天枢”(st 25)和“上巨虚”(st 37)对精神状态、内脏敏感性及神经生长因子(ngf)、酪氨酸激酶受体a(trka)蛋白表达的影响。