Mar 6, 2024 · We demonstrate that ST3Gal1 plays an important role in modulating tumour immune evasion through the synthesises of sialoglycans with the capacity to engage the Siglec-7 and Siglec-9...

Dec 25, 2024 · ST3GAL1 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1) is a Protein Coding gene. Diseases associated with ST3GAL1 include Puerperal Pulmonary Embolism and Nonaka Myopathy. Among its related pathways are Early SARS-CoV-2 Infection Events and Translation of Structural Proteins.

靶向ST3GAL1-βII-spectrin轴可改善T细胞到肿瘤细胞靶点的归巢，提高T细胞免疫治疗的疗效，同时降低与非特异性细胞毒性相关的风险。 为了发现调控CAR-T细胞在体内迁移到非特异性部位的基因，研究人员首先利用CRISPR-Cas9功能缺失筛选技术，鉴定出 St3gal1 和 Spc24 是 ...

Oct 30, 2018 · ST3GAL1 is a sialyltransferase that catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and is...

ST3GAL1 promotes cell migration, invasion, and TGFB1-induced epithelial-mesenchymal transition and confers paclitaxel resistance in ovarian cancer. Data suggest that GDNF family receptor alpha 1 protein (GFRA1) is a protein target of ST3 beta-galactoside alpha-23-sialyltransferase 1 (ST3GAL1).

ST3Gal1是关键的唾液酸转移酶，可将α2,3连接的唾液酸添加至底物并生成核心1 O聚糖结构。 ST3Gal1的上调与乳腺癌患者的预后较差有关。 但是，与肿瘤进展有关的ST3Gal1的蛋白质底物仍然难以捉摸。

Apr 17, 2023 · These findings identify the ST3GAL1–βII-spectrin axis as a major cell-intrinsic program for cancer-targeting CAR T cell migration and as a promising strategy for effective T cell immunotherapy.

Here, with a CRISPR-Cas9 pooled library, we performed an in vivo targeted loss-of-function screen and identified ST3 β-galactoside α-2,3-sialyltransferase 1 (ST3GAL1) as a negative regulator of the cancer-specific migration of CAR T cells. Analysis of glycosylated proteins revealed that CD18 is a major effector of ST3GAL1 in activated CD8 + T ...

该基因编码的蛋白质是一种 II 型膜蛋白，可催化唾液酸从 CMP-唾液酸转移到含半乳糖的底物。 编码的蛋白质通常存在于高尔基体中，但可以通过蛋白水解加工成可溶性形式。 编码蛋白质的正确糖基化可能对其唾液酸转移酶活性至关重要。 这种蛋白质是糖基转移酶家族 29 的成员，可以使用与唾液酸转移酶 4B 相同的受体底物。 已发现该基因编码相同蛋白质的两个转录变体。 可能存在其他转录变体，但尚未完全表征。 [RefSeq 提供，2008 年 7 月]

Nov 17, 2020 · ST3GAL1 induces AXL dimerization and activation that, in turn, promotes melanoma invasion. Our data support a key role of the ST3GAL1-AXL axis as driver of melanoma metastasis, and highlight the therapeutic potential of targeting this axis to …