2024年12月25日 · STAB1 (Stabilin 1) is a Protein Coding gene. Diseases associated with STAB1 include Hyperferritinemia and Histiocytosis. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport.

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene. [5] [6] [7] This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging.

2024年12月10日 · Title: A form of inherited hyperferritinemia associated with bi-allelic pathogenic variants of STAB1. Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis.

该基因编码一种大的跨膜受体蛋白，该蛋白可能在血管生成、淋巴细胞归巢、细胞粘附或受体清除中发挥作用。 该蛋白质包含 7 个成束蛋白、16 个表皮生长因子 (EGF) 样结构域和 2 个层粘连蛋白型 EGF 样结构域以及一个 C 型凝集素样透明质酸结合连接模块。 该蛋白主要在肝、脾和淋巴结的窦状内皮细胞上表达。 该受体已被证明可以内吞配体，例如低密度脂蛋白、革兰氏阳性和革兰氏阴性细菌，以及高级糖基化终产物。 支持其作为清道夫受体的可能作用，该蛋白质在质膜和早 …

The multifunctional scavenger receptor stabilin-1 (STAB1, FEEL-1, CLEVER-1, KIAA0246) was originally identified as the MS-1 antigen, expressed by sinusoidal endothelial cells in human spleen. Extensive histological studies revealed that stabilin-1 is also expressed by tissue macrophages and sinusoid …

2024年2月22日 · The STAB1 gene encodes the multifunctional scavenger receptor stabilin-1. Stabilin receptors are transmembrane proteins with a large extracellular N terminus containing EGF-like domains and a short intracellular C-terminal domain that is highly diverse.

背景：清道夫受体 Stabilin-1 (Stab1) 和 Stabilin-2 (Stab2) 优先由肝窦内皮细胞表达。 它们介导控制远处器官稳态的循环血浆分子的清除。 研究表明 Stab1 和 Stab2 可能影响动脉粥样硬化。

2025年2月8日 · A form of inherited hyperferritinemia associated with bi-allelic pathogenic variants of STAB1. Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis.

4 天之前 · STAB1 knockdown inhibits AML cell growth while inducing macrophage polarization and activating a pro-inflammatory microenvironment through NF-κB pathway activation. Thus, the development of therapeutics targeting STAB1 could potentially serve as a valuable strategy for improving the efficacy of AML treatments.

Predicted to be located in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; lung epithelium; and retina nuclear layer. Orthologous to human STAB1 (stabilin 1). [provided by Alliance of Genome Resources, Apr 2022]