Src是一种与细胞膜相关的非受体酪氨酸激酶，在肿瘤细胞的增殖、迁移和分化过程中发挥关键作用。 在分子水平上，Src诱导酪氨酸残基磷酸化从而使STAT3活化。

STAT3是许多细胞因子（白细胞介素IL-6，IL-10和IL-11等）、生长因子（Fibroblast growth factor，FGF；Vascular endothelial growth factor ，VEGF等）、以及一些原癌基因（K-Ras，Src和cAbl等）激活的信号通路的汇合点。

Signal transducers and activators of transcription (STAT) proteins are a family of cytoplasmic transcription factors with similar structure that are activated by tyrosine kinase signals. 21–24 STATs are activated when critical tyrosine residues become phosphorylated by protein tyrosine kinases, including membrane-bound growth factor receptors ...

Janus激酶（JAK）信号转导和转录激活因子（JAK-STAT）途径是一种进化上保守的信号通路，由细胞因子刺激激活，使细胞外信号通过细胞膜传递到细胞核，引起DNA转录的改变，在几个关键的生理过程中发

2001年5月3日 · Using tyrosine kinase selective inhibitors, we show here that Src and JAK family tyrosine kinases cooperate to mediate constitutive Stat3 activation in the absence of EGF stimulation in model...

2001年6月12日 · Signal transducer and activator of transcription (STAT) proteins perform key roles in mediating signaling by cytokines and growth factors, including platelet-derived growth factor (PDGF). In addition, Src family kinases activate STAT signaling and are required for PDGF-induced mitogenesis in normal cells.

2004年10月18日 · In the case of cytokine receptors, activation of STAT tyrosine phosphorylation occurs through ligand-induced recruitment, and activation of the intracellular JAK kinases. However, STATs can...

2001年5月3日 · Inhibition of Src or JAKs results in dose-dependent suppression of Stat3 DNA-binding activity, which is accompanied by growth inhibition and induction of programmed cell death. In addition, transfection of a dominant-negative form of Stat3 leads to growth inhibition involving apoptosis of breast cancer cells.

We conclude that Stat3 activation by the Src oncoprotein leads to specific gene regulation and that Stat3 is one of the critical signaling pathways involved in Src oncogenesis. Our findings provide evidence that oncogenesis-associated activation of Stat3 signaling is part of the process of malignant transformation.

2025年3月18日 · Signal transducer and activator of transcription (STAT) family members mediate signaling in the Janus kinase (JAK)–STAT pathway and are activated by phosphorylation at a conserved tyrosine residue, resulting in dimerization through reciprocal interactions between the phosphotyrosine and a Src homology 2 (SH2) domain.