Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are effective in the treatment of dyslipidemia and have been shown to reduce the risk of major coronary …

The cytochrome P450 family consists of major enzymes involved in drug metabolism and bioactivation. This article aims to highlight drug interactions involving statins, as well as …

The primary form of drug metabolism for most statins occurs through CYP450 enzymes. The most prevalent CYP450 enzyme subcategories for statin metabolism are the 3A4 and 2C9 enzyme …

Although traditional models attribute statin metabolism to the cytochrome hepatic systems, more contemporary theories involve classification of potential pathways as follows: a lipophilic …

Generally, the statins are the substrates of CYP enzymes, P-glycoprotein (P-gp), and organic anion transporting polypeptides transporters (OATP1B1). Objective: This review article …

2014年2月27日 · Enterocyte cytochrome P450 (CYP) may metabolize some statins before eventual absorption into the portal circulation. Hepatic uptake is mediated by several …

Simvastatin and atorvastatin, two widely prescribed cholesterol lowering medicines, are both metabolised by the isoenzyme cytochrome P450 3A4 (CYP3A4). Simvastatin undergoes more …

Purpose: The co-administration of cytochrome P450 3A4 (CYP3A4) inhibitors with simvastatin or atorvastatin (CYP3A4-metabolised statins) is associated with increased statin exposure and …

Potentially interacting drugs included inhibitors and inducers of cytochrome P450 (CYP) enzymes and drugs of narrow safety margin (coumarin anticoagulants, digitalis). The proportion of …

2014年10月1日 · Statins are predominantly metabolized by the cytochrome P-450 (CYP) system. The exceptions, i.e. pravastatin and rosuvastatin, are hydrophilic molecules undergoing …