2023年4月11日 · Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a …

2023年10月15日 · STEAP1 is now drawing attention as a promising therapeutic target because of its tumor specificity and membrane-bound localization. The clinical efficacy of an antibody …

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple …

2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer …

• STEAP1 is a membrane protein that is overexpressed in > 80% of prostate cancers, representing an attractive target for treating mCRPC 11-13 • Several modalities are being …

2012年5月1日 · STEAP1 actively increases intra- and intercellular communication through the modulation of Na +, Ca 2+, and K + concentration, as well as the concentration of small …

STEAP1 and STEAP1B gene share high homology and are differentially expressed in human prostate cell lines. A detailed in silico analysis allowed to compare the genomic organization of …

2024年7月3日 · AMG 509 is a humanized T-cell engager (TCE) molecule targeting STEAP1, which has shown promising results in phase I trials for metastatic castration-resistant prostate …

STEAP1, in particular, is highly expressed on the plasma membrane of prostate cancer cells and has received significant attention as a potential therapeutic target. This review highlights what …

STEAP1, Six Transmembrane Epithelial Antigen of Prostate member 1, is highly expressed in several types of cancer cells, particularly in prostate cancer, and inhibition of its expression …