2023年4月11日 · We engineer and screen second-generation STEAP1 CARs for antigen-specific T cell activation and target cell cytolysis to yield a lead candidate for further characterization. We determine the...

2024年1月12日 · Xaluritamig contains two identical humanized anti-STEAP1 fragment antigen–binding domains that bind STEAP1-expressing cells, an anti-CD3 single-chain variable fragment domain that binds T cells to facilitate T cell–mediated lysis, and an effectorless Fc domain that extends serum half-life.

STEAP1属于前列腺六跨膜上皮抗原（STEAP）家族，该家族除STEAP1外，还有STEAP2、STEAP3、STEAP4，他们参与许多生物过程，包括细胞凋亡和增殖、氧化应激及胞内外分子运输。

2024年1月12日 · We developed a STEAP1-targeted XmAb 2+1 T-cell engager (TCE) molecule, AMG 509 (also designated xaluritamig), that is designed to redirect T cells to kill prostate cancer cells that express STEAP1.

AMG 509是一款靶向STEAP1的人源化的 TCE分子，在一期转移性去势耐受性癌症（mCRPC）上的亮眼成绩，单药PSA50为49%，客观有效率（ORR）为24%；毒性稍高但是整体安全性算良好。 那STEAP1究竟是怎样一个靶点？ 目前相关临床药物布局又是如何？ 六跨膜前列腺上皮抗原1（STEAP1），又称为PRSS2或STEA1，属于前列腺六跨膜上皮抗原（STEAP）家族，该家族还包含成员STEAP1B、STEAP2、STEAP3、STEAP4。 其中，STEAP1B是STEAP1的截短同 …

2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer.

2023年10月15日 · STEAP1 is now drawing attention as a promising therapeutic target because of its tumor specificity and membrane-bound localization. The clinical efficacy of an antibody-drug conjugate targeting STEAP1 in metastatic, castration-resistant, prostate cancer was demonstrated in a phase 1 trial.

Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen highly expressed in prostate cancer, strongly expressed in >80% of mCRPC with bone or lymph node involvement, and often associated with poor survival. 1 Xaluritamig is a novel bispecific XmAb® 2+1 T-cell engager targeting STEAP1 and designed to facilitate ...

2012年5月1日 · STEAP1 actively increases intra- and intercellular communication through the modulation of Na +, Ca 2+, and K + concentration, as well as the concentration of small molecules. It stimulates cancer cell proliferation and tumor invasiveness.

2024年11月14日 · 前列腺六跨膜上皮抗原（STEAP1）属于STEAP家族，STEAP1首次在晚期前列腺癌中被发现，是一种充当转运蛋白的细胞表面蛋白，是肿瘤细胞和邻近肿瘤基质细胞之间细胞间通讯以促进肿瘤生长所必需的。