Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene. [5] [6] [7] This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in …

2024年12月25日 · STEAP2 (STEAP2 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP2 include Hepatic Adenomas, Familial and Prostate Cancer. Among its related pathways is Copper homeostasis. Gene Ontology (GO) annotations related to this gene include transporter activity and ferric-chelate reductase (NADPH) activity.

2012年5月1日 · Schematic of STEAP2 protein structure, cellular localization, and physiologic functions. Because of its metalloreductase activity, STEAP2 contributes to proper erythrocyte Fe 3+ and Cu 2+ uptake and their reduction to Fe 2+ and …

The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4. All of these proteins are unique to mammals and share an innate activity as metalloreductases, indicating their importance in metal metabolism.

2024年6月3日 · Six Transmembrane Epithelial Antigen of Prostate 2 (STEAP2) belongs to a family of metalloreductases, which indirectly aid in uptake of iron and copper ions. Its role in hepatocellular...

2024年1月11日 · This study emphasized the therapeutic potential of STEAP2 and further promoted the development of DNTGF-βRII-armored CAR-T cell therapy. Head-to-head comparisons between DNR technology and other signaling blockade strategies

The STEAP2 gene, also known as STAMP1, is located on chromosome 7q21.13 and is situated near STEAP1 and STEAP4. It consists of six exons and five introns, encoding 490 amino acids . In addition, the expression of STEAP2 in breast cancer tissues and cells has been reported to …

2018年4月19日 · Six-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer...

2024年1月8日 · The six-transmembrane epithelial antigen of prostate (STEAP) family of proteins are located on the cell surface, and it comprises 4 members, named STEAP1, STEAP2, STEAP3, and STEAP4. Cumulative evidence has revealed that STEAPs are abnormally expressed in various cancer tissues and cell lines [ 4 , 5 ], and are significantly associated with ...

2025年2月8日 · STEAP2 drives aggressive prostate cancer traits by promoting proliferation, migration and invasion and significantly influencing the transcriptional profile of ten genes underlying the metastatic cascade.