2024年12月25日 · STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by …

stip1 是一种衔接蛋白，可协调 hsp70 (参见 hspa1a；mim 140550) 和 hsp90 (参见 hsp90aa1；mim 140571) 在蛋白质折叠中的功能。它被认为通过结合 hsp90 和底物结合的 hsp70 来帮助蛋白质从 hsp70 转移到 hsp90。

Stress-induced-phosphoprotein 1 also Hsp70-Hsp90 organising protein (Hop) is encoded in the human by the STIP1 gene. It functions as a co-chaperone which reversibly links together the protein chaperones Hsp70 and Hsp90 .

2025年2月9日 · STIP1 is positively associated with sublethal heat-induced cancer cell metastasis through mediating the mesenchymal gene transcription. High STIP1 expression was significantly associated with shorter overall survival, earlier lymph node metastasis and more advanced clinical stage compared with low STIP1 expression in cancer.

2018年3月29日 · Stress-induced phosphoprotein 1 (STIP1, also known as heat shock protein [HSP] 70/90 organizing protein, Gene ID 10963) is a 62.6-kDa protein that acts as a co-chaperone of HSPs. It...

2020年4月30日 · Stress-inducible phosphoprotein 1 (STIP1) is a well-described co-chaperone of the Hsp90 chaperone system, and our findings identify a potential regulatory role of STIP1 in actin dynamics.

2025年1月4日 · STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by …

2024年9月12日 · STIP1（Stress-Induced Phosphoprotein 1），也称为HSP70-HSP90 Organizing Protein（HOP），是一种在细胞应激、蛋白质折叠和细胞信号传导中起重要作用 的蛋白质。

Abstract. Stress-induced phosphoprotein 1 (STIP1) has been recently identified as a released biomarker in human ovarian cancer. In addition, STIP1 secreted by human ovarian cancer cells has been shown to promote tumor cell proliferation by binding to ALK2 (activin A receptor, type II-like kinase 2) and activating the SMAD-ID3 signaling pathways.

2024年9月12日 · STIP1（Stress-Induced Phosphoprotein 1），也称为HSP70-HSP90 Organizing Protein（HOP），是一种在细胞应激、蛋白质折叠和细胞信号传导中起重要作用 的蛋白质。 作为一种分子伴侣，STIP1在维持细胞内蛋白质稳定性和功能方面发挥 关键作用。