Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene. STK33 was identified as a synthetic lethal gene in KRAS -dependent cell lines. [5] STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice. [6] ^ "Human PubMed Reference:".

2024年12月25日 · STK33 (Serine/Threonine Kinase 33) is a Protein Coding gene. Diseases associated with STK33 include Spermatogenic Failure 93 and Pancreatic Cancer. Among its related pathways are Sweet Taste Signaling and MAP Kinase Signaling.

2024年5月23日 · Men or mice with homozygous serine/threonine kinase 33 (STK33) mutations are sterile owing to defective sperm morphology and motility. To chemically evaluate STK33 for male contraception with STK33-specific inhibitors, we screened our multibillion-compound collection of DNA-encoded chemical libraries, uncovered potent STK33-specific inhibitors ...

2018年1月1日 · Here we report that the serine/threonine kinase Stk33 is essential for the differentiation of round spermatids into functional sperm cells and male fertility. Constitutive Stk33 deletion in mice results in severely malformed and immotile spermatozoa that are particularly characterized by disordered structural tail elements.

2025年2月9日 · STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity. Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC).

2015年2月7日 · STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 cells. In addition, this protein also promotes epithelial–mesenchymal transition (EMT).

stk33表达异常肿瘤侵袭性更强，不过其在胃癌中的表达、临床意义和生物学功能研究较少。 研究者探讨了胃癌中STK33的表达和Krüppel样因子/STK33信号通路的临床意义，用免疫组化方法检测了胃癌组织中的STK33表达，分析其与临床病理特征的关系，STK33敲除和过表达 ...

STK33，即丝氨酸/苏氨酸激酶33，它是一种在人体多种组织中表达的蛋白激酶，属于钙/钙调蛋白依赖性激酶家族成员。 STK33在细胞中的表达受细胞密度控制，并且在头颈肿瘤等手术切除标本中的表达量显著高于正常或癌旁组织。 其作用机制涉及自磷酸化功能，能够对下游基因如Vimentin蛋白进行磷酸化修饰，影响其生物学功能。 STK33还可能通过非激酶活性依赖途径影响C-Myc基因的转录作用。 在信号通路方面，STK33与ERK1/2信号通路存在交互作用，可能参与调控细胞增 …

丝氨酸/苏氨酸激酶33 (serine/threonine kinase 33,STK33)是近年来倍受生物学界关注的一种蛋白因子。 它并非普遍表达,且在大多数组织中表达水平较低。 虽然STK33属于钙离子/钙调素依赖性蛋白激酶 (Ca~ (2+)/calmodulindependent protein kinase,CAMK)家族,但是STK33在表达模式上与某些CAMK家族亚型成员有一定的差异。 STK33可能通过特异性磷酸化波形蛋白,参与中间丝细胞骨架解聚的动态变化,影响细胞的结构和一系列重要的功能,进而参与肿瘤的发生和发展过程。 …

Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues. 预测启用蛋白质丝氨酸/苏氨酸激酶活性。 预计参与有丝分裂 DNA 损伤检查点信号和蛋白质自磷酸化。 预测位于细胞质的核周区。 预计在细胞质和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and protein autophosphorylation.