2024年12月25日 · STK38L (Serine/Threonine Kinase 38 Like) is a Protein Coding gene. Diseases associated with STK38L include Bardet-Biedl Syndrome 18 and Ossification Of The Posterior Longitudinal Ligament Of Spine. Among its related pathways …

2025年2月8日 · Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. The results demonstrate that NDR2 is a reversible acetylated kinase regulated by SIRT1 and p300/CBP.

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene. [5] [6]

To explore the mechanism underlying myocardial fibrosis, we aimed to determine whether serine/threonine kinase 38 like (STK38L) contributes to the development of myocardial fibrosis by regulating the proliferation and activation of CFs triggered by TGF-β1.

Recently, the role of Serine-threonine kinase 38 (STK38) in DNA-damage signaling is emerging. Here, we aim to provide an overview of current topics of STK38 in common mechanisms of regulation, DNA damage signaling, cross-talk between the DDR pathways, cancer, and the potential application for radiotherapy.

Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues. 启用 ATP 绑定活动；镁离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。 参与细胞内信号转导。 作用于蛋白质磷酸化的上游或内部。 位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月] Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction.

2024年12月25日 · STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are RHOBTB GTPase Cycle and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. …

2019年11月1日 · Our findings demonstrate two novel association between the glioma risk region marked by variant rs10842893 and rs4774756) and glioma risk. These findings may advance the understanding of genetic susceptibility to glioma. Keywords: GWAS; RAB27A; STK38L; glioma; oncogene. © 2019 UICC.

2022年6月7日 · Our study identifies a key role of STK38L‐TRIM27‐ULK1 signaling axis in negatively controlling autophagy with relevance established in human breast cancer. While ULK1 is essential for autophagy initiation, the mechanisms controlling its …

2015年5月18日 · Here we demonstrate that Stk38 negatively regulates TLR9-mediated immune responses in macrophages. Stk38 constitutively associates with ubiquitin E3 ligase Smurf1, and facilitates Smurf1-mediated...