STMN2 Gene - GeneCards | STMN2 Protein | STMN2 Antibody
2024年12月25日 · STMN2 (Stathmin 2) is a Protein Coding gene. Diseases associated with STMN2 include Trichorhinophalangeal Syndrome, Type Ii and Creutzfeldt-Jakob Disease. …
Neuron综述｜肌萎缩侧索硬化症（ALS）的发病机制和基因治疗方 …
TDP-43的剪接靶点stathmin-2（STMN2）有可能在ALS中发挥关键作用。 研究发现下调TDP-43水平会导致数百个基因的表达发生变化，其中微管稳定调节因子STMN2是下调最严重的基因之一。
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS ... - Cell …
Constitutive STMN2 loss results in early-onset sensory and motor neuropathy featuring impaired motor behavior and dramatic distal neuromuscular junction (NMJ) denervation of fast-fatigable …
Mechanism of STMN2 cryptic splice-polyadenylation and its …
2023年3月17日 · TDP-43 mislocalization results in cryptic splicing and polyadenylation of pre-messenger RNAs (pre-mRNAs) encoding stathmin-2 (also known as SCG10), a protein that is …
科学家揭示STMN2隐性剪接多腺苷化的机制及其对TDP-43蛋白病 …
2023年3月17日 · We found that TDP-43 binding to a GU-rich region sterically blocked recognition of the cryptic 3′ splice site in STMN2 pre-mRNA. Targeting dCasRx or antisense …
STMN2 - Wikipedia
20257 Ensembl ENSG00000104435 ENSMUSG00000027500 UniProt Q93045 P55821 RefSeq (mRNA) NM_001199214 NM_007029 NM_025285 RefSeq (protein) NP_001186143 …
Loss of mouse Stmn2 function causes motor neuropathy - Cell Press
2022年3月15日 · Both mosaic founders and homozygous loss-of-function Stmn2 mice exhibited neuromuscular junction denervation and fragmentation, resulting in muscle atrophy and …
ALS-implicated protein TDP-43 sustains levels of STMN2, a ... - Nature
2019年1月14日 · STMN2 loss upon reduced TDP-43 function was due to altered splicing, which is functionally important, as we show STMN2 is necessary for normal axonal outgrowth and …
STMN2 stathmin 2 [Homo sapiens (human)] - Gene - NCBI
2025年2月9日 · STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFbeta signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in …
11075 - Gene ResultSTMN2 stathmin 2 [ (human)] - National …
2025年2月9日 · STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFbeta signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in …