STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). [5] [6]

2024年12月25日 · STUB1 (STIP1 Homology And U-Box Containing Protein 1) is a Protein Coding gene. Diseases associated with STUB1 include Spinocerebellar Ataxia, Autosomal Recessive 16 and Spinocerebellar Ataxia 48. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Gene expression (Transcription).

2023年9月1日 · The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13.3, encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase involved in protein quality control. CHIP comprises three domains: an N-terminal tetratricopeptide repeat (TPR) domain, a middle coiled-coil domain, and a C-terminal U-box ...

2022年4月8日 · STUB1 mediates ubiquitination-dependent proteasomal degradation of IFNγ-R1/JAK1 complex through IFNγ-R1 K285 and JAK1 K249. Conversely, STUB1 inactivation amplifies IFNγ signaling, sensitizing...

CHIP (carboxyl terminus of Hsc70-interacting protein)又称STUB1 (STIP1 homology and U-box containing protein 1)，是一种分子伴侣结合蛋白，具有E3泛素连接酶活性．研究表明，CHIP蛋白在细胞体内通过蛋白质量控制系统调控细胞代谢、分化、增殖、迁移和肿瘤发生发展等多种生理病 …

研究发现stub1及mettl3能够调控及回复mettl14的细胞学功能。 进一步通过小鼠皮下注射 胆管癌 细胞建立胆管癌发展模型，验证m6A甲基转移酶以及STUB1对癌症发展的作用，揭示 靶向m

2022年8月18日 · Results from a published CRISPR screen in a mouse model suggested that targeting STUB1, an E3 ligase involved in protein homeostasis, may overcome ICB resistance but the molecular basis of this...

STUB1 expression attenuates hydrogen peroxide–induced cell senescence, indicated by a reduced signal in senescence-associated β-gal staining and decreased protein levels of two cell senescence markers, p53 and p21. BMAL1 knockdown diminishes this effect, and BMAL1 overexpression abolishes STUB1's effect on cell senescence.

该基因编码一种含有四肽重复序列的蛋白质和一个作为泛素连接酶/辅伴侣的 U 盒。 编码的蛋白质结合并泛素化休克同源 71 kDa 蛋白质 (Hspa8) 和 DNA 聚合酶 beta (Polb) 以及其他目标。 该基因的突变导致脊髓小脑性共济失调，常染色体隐性遗传 16。 可变剪接导致多种转录本变异。 该基因在 2 号染色体上有一个假基因。 [RefSeq 提供，2014 年 6 月] This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin Ligase /cochaperone.

2024年11月26日 · Zhang et al. illustrate the function and the mechanism of the STUB1/NSUN2/GPX4 axis in hepatocyte ferroptosis. Downregulation of NSUN2 by STUB1-mediated ubiquitination alleviates Gpx4 mRNA m5C modification and inhibits GPX4 protein expression, which promotes cellular sensitivity to ferroptosis in vivo and in vitro.