2024年12月25日 · STX6 (Syntaxin 6) is a Protein Coding gene. Diseases associated with STX6 include Pontocerebellar Hypoplasia, Type 2E and Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Vesicle-mediated transport.

The protein domain Syntaxin 6 N terminal protein domain is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) found in endosomal transport vesicles. It is part of the family, of target SNAREs (t-SNAREs). It is a vital aid to exporting and importing cell cargo through a process called cell trafficking.

2022年12月21日 · Syntaxin-6 (STX6), a vesicular transport protein, is a direct target of the tumor suppressor gene P53, supporting cancer growth dependent on P53. However, STX6's function in the tumor microenvironment has yet to be reported. In this research, we comprehensively explored the role of the oncogene STX6 …

2023年7月31日 · Gain- and loss-of-function experiments showed that STX6 promotes cell proliferation and metastasis of HCC cells both in vitro and in vivo. Mechanistically, STX6 was negatively regulated by the upstream stimulatory factor 2 (USF2). In addition, STX6 facilitates the association of autophagosomes with lysosomes.

2008年11月7日 · Here, we found that the gene encoding STX6 (syntaxin 6), a vesicle transporter protein, is directly regulated by each of the p53 family proteins. In addition, STX6 can be induced by DNA damage and Mdm2 inhibitor Nutlin-3 in a p53-dependent manner.

突触融合蛋白 6： 启用 syntaxin 绑定活动。参与多个过程，包括高尔基带形成；逆行运输，内体到高尔基体；和囊泡融合。作用于内吞循环的上游或内。位于多种细胞成分中，包括早期内体；细胞质的核周区；和跨高尔基网络。 SNARE 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

2024年6月4日 · Syntaxin6 (STX6) is a SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein complex located in the trans-Golgi network and endosomes, which is closely associated with a variety of intracellular membrane transport events.

2017年1月2日 · Here, we demonstrate that STX6 (syntaxin 6) is recruited to GcAVs and forms a complex with VTI1B and VAMP3 to regulate the GcAV-RE fusion that is required for xenophagy. STX6 targets the GcAV membrane through its tyrosine-based sorting motif and transmembrane domain, and localizes to TFRC (transferrin receptor)-positive punctate structures on ...

2022年12月21日 · Syntaxin-6 is a direct target of P53 and has been proven to be an oncogene in several types of cancer. In this research, we comprehensively analyzed the carcinogenic role of STX6 in pan-cancer, and we found that STX6 may also play an essential role in the tumor microenvironment, and that knocking down STX6 could enhance the effect of anti-PD-1.

Syntaxin-6 is a direct target of P53 and has been proven to be an oncogene in several types of cancer. In this research, we comprehensively analyzed the carcinogenic role of STX6 in pan-cancer, and we found that STX6 may also play an essential role in the tumor microenvironment, and that knocking down STX6 could enhance the effect of anti-PD-1.