2024年12月25日 · STYK1 (Serine/Threonine/Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with STYK1 include Cervix Carcinoma. Among its related pathways is Focal adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

2019年6月4日 · STYK1 overexpression promoted NSCLC cells proliferation, migration, and invasion. STYK1 also induced epithelial–mesenchymal transition by E-cadherin downregulation and Snail upregulation.

2016年9月15日 · Our results suggest that STYK1 acts as an oncogene by inducing cell invasion and EMT via the MEK/ERK and PI3K/AKT signaling pathways and it therefore may be a potential therapeutic target in HCC.

2024年10月16日 · The serine/threonine/tyrosine kinase 1 (STYK1) is a receptor protein-tyrosine kinase (RPTK)-like molecule that is detected in several human organs. STYK1 plays an important role in promoting tumorigenesis and metastasis in various cancers. By analyzing the expression of RTKs in immune cells in the d …

elevated serine threonine tyrosine kinase 1 (STYK1) or decreased serine peptidase inhibitor Kunitz type 2 (SPINT2/HAI-2) expression significantly correlated with poor prognosis, tumor invasion, and metastasis of NSCLC patients. STYK1 overexpression promoted NSCLC cells proliferation, migration, and invasion.

We demonstrated that Styk1 expression is a hallmark of NK cells and other NK1.1 expressing cells such as liver type 1 innate lymphoid cells (ILC1) and NK1.1 + γδ T cells. Styk1 expression is maintained by IL-15 in NK cells and negatively correlates with the …

2018年4月1日 · In the present study, STYK1 overexpression or knockdown in a variety of GBC cells has demonstrated that STYK1 possesses the ability to promote tumor cell growth, cell survival, anti-apoptosis, and EMT.

Serine/threonine/tyrosine kinase 1 (STYK1) has been previously shown to have oncogenic properties, and emerging evidence suggests that STYK1 expression correlates with epithelial-mesenchymal transition (EMT).

Preferential Styk1 expression in mammalian NK cells correlates with the conserved location of the Styk1 gene at the border of the NK-complex on mouse chromosome 6 and human chromosome 12 (Figure 1A). Analyses of genomic data from 28 mouse strains suggest the presence of a functional Styk1 allele in all of them [ 19 ].

In this study, we showed that STYK1 expression is upregulated in human glioma cell lines. Knockdown of STYK1 inhibited cell proliferation, migration, and invasion in vitro and tumor growth in vivo. Furthermore, knockdown of STYK1 markedly inhibited phosphorylation levels of PI3K and Akt in U87MG cells.