2006年3月20日 · Here, we demonstrate that both Nde1 and Su48 can associate with p78/MCRS1, a protein implicated in cancer development. We found that, whereas the majority of p78 localizes to the nucleus as...

2006年4月4日 · In the current study, we cloned and characterized a centrosome-associated protein named Su48. We identified a subdomain of Su48 that contains a coiled-coil motif and is important for its dimerization and localization to the centrosome. Moreover, we determined whether interference with Su48 function affects mitosis.

Finally, by microinjection of an anti-Su48 antibody, we found that In the current study, we cloned and characterized a centrosome- disruption of normal Su48 functions leads to mitotic failure, possibly associated protein named Su48. We identified a subdomain of Su48 due to centrosome defects or incomplete cytokinesis.

We next determined the Su48 structure involved in binding to Nde1. By a similar immunoprecipitation approach, we assessed the association between Nde1 and a series deleted form of Su48. Our ...

2006年4月25日 · We found that a coiled coil-containing subdomain of Su48 was both sufficient and required for its centrosome localization. In addition, this structure also modulates Su48 dimerization. Moreover, ectopic expression of Su48 causes abnormal mitosis, and a mutant form of Su48 disrupts the localization of γ-tubulin to the centrosome.

2006年8月10日 · Here, we demonstrate that both Nde1 and Su48 can associate with p78/MCRS1, a protein implicated in cancer development. We found that, whereas the majority of p78 localizes to the nucleus as reported in earlier studies, a fraction of the p78 protein can be detected in the centrosome.

2006年4月25日 · We found that a coiled coil-containing subdomain of Su48 was both sufficient and required for its centrosome localization. In addition, this structure also modulates Su48 dimerization. Moreover, ectopic expression of Su48 causes abnormal mitosis, and a mutant form of Su48 disrupts the localization of gamma-tubulin to the centrosome.

2006年5月1日 · We found that a coiled coil-containing subdomain of Su48 was both sufficient and required for its centrosome localization. In addition, this structure also modulates Su48 dimerization....

2015年10月15日 · By immunofluorescence microscopy, Wang et al. (2006) found that ZNF365A, which they called SU48, localized to the centrosome throughout the cell cycle in several human cell lines. The centrosomal localization of ZNF365A was not affected by a microtubule depolymerizing agent.

Download scientific diagram | Su48 is expressed in a variety of tissues and cancer cell lines. (A) RT-PCT analysis of Su48 expression. cDNA samples were prepared from various mouse tissues (1 ...