2011年4月15日 · Suppressor of fused (Sufu) is an essential negative regulator of the sonic hedgehog (Shh) pathway, but little is known about how Sufu itself is normally regulated. Here, …

Here, we report that Sufu is phosphorylated at Ser-342 and Ser-346 by GSK3β and cAMP-dependent protein kinase A (PKA), respectively, and phosphorylation at this dual site stabilizes …

SUFU interaction with PKA and GSK3β can prevent its nuclear degradation and stabilize Hh/GLI signaling. It was recently discovered that SUFU can interact with protein phosphatase 4 …

2020年8月11日 · Reversible phosphorylation of Suppressor of fused (Sufu) is essential for Sonic Hedgehog (Shh) signal transduction. Sufu is stabilized under dual phosphorylation of protein …

2021年2月19日 · It has also been shown that dual phosphorylation of SuFu by PKA and GSK3β leads to SuFu stabilization 30, while dephosphorylated SuFu is recognized by Fbxl17 for Skp1 …

Here, we report that Sufu is phosphorylated at Ser-342 and Ser-346 by GSK3 and cAMP-dependent protein kinase A (PKA), respectively, and phosphor-ylation at this dual site …

2017年12月12日 · Here, we report new findings of Sufu in regulating the epithelial-to-mesenchymal transition through the FoxM1 transcriptional modulation by 14-3-3ζ protein in …

蛋白激酶，如 PKA、GSK3β 和 CK1α，磷酸化 GLI2 和 GLI3，导致蛋白体介导全长 Gli 裂解为截短形式 Gli2R、Gli3R，并作为 Hh 靶基因表达的阻遏物。 此外，Sufu 通过与细胞质和细胞核 …

gli 蛋白还通过纤毛进行转运，并在缺乏 hh 信号转导的情况下被 sufu 和 kif7 隔离，从而通过 pka、gsk3β 和 ck1 实现 gli 磷酸化，随后加工成为转录抑制因子（通过羧基末端的剪切）或靶向降 …

Here, we report that Sufu is phosphorylated at Ser-342 and Ser-346 by GSK3β and cAMP-dependent protein kinase A (PKA), respectively, and phosphorylation at this dual site stabilizes …