Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. [5] Survivin is a member of the inhibitor of apoptosis (IAP) family.

Survivin是凋亡抑制蛋白家族的新成员，Survivin具有肿瘤特异性，只表达于肿瘤和胚胎组织，且与肿瘤细胞的分化增殖及浸润转移密切相关。 有学者研究了Survivin基因在鼻型NK/T细胞淋巴瘤的表达及其与p53、bcl 2蛋白表达的相关性。

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin has consistently been identified by …

Pursuing the nodal functions of survivin in cancer might lead to the development of global pathway inhibitors with unique therapeutic potential.

2016年6月23日 · Expression of Survivin in tumours correlates with not only inhibition of apoptosis and a decreased rate of cell death, but also resistance to chemotherapy and aggressiveness of tumours. Therefore, Survivin is an important target for cancer vaccines and therapeutics.

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin has consistently been identified by ...

Several molecular lesions associated with cancer have been implicated in the potential deregulation of survivin gene expression, including amplification of the survivin locus on 17q25 in ...

2015年6月25日 · Survivin是Ambrosini等 用效应细胞蛋白酶受体1(effect cell protease receptor 1,EPR-1) cDNA与人类基因库杂交分离得到，由于含有杆状病毒IAP重复序列(baculovirus IAP repeat，BIR)区并可直接抑制凋亡酶的活性而归属于凋亡抑制蛋白(inhibitor of apoptosis protein，IAP)家族。研究表明，它在 ...

2003年11月24日 · Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research.