Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. [5] Survivin is a member of the inhibitor of apoptosis (IAP) family.

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome.

Survivin是凋亡抑制蛋白家族的新成员，Survivin具有肿瘤特异性，只表达于肿瘤和胚胎组织，且与肿瘤细胞的分化增殖及浸润转移密切相关。 有学者研究了Survivin基因在鼻型NK/T细胞淋巴瘤的表达及其与p53、bcl 2蛋白表达的相关性。 结果发现鼻型NK/T细胞淋巴瘤Survivin基因表达上调，并与p53高表达密切相关，但与bcl 2蛋白无明显关联。

2016年6月23日 · Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent …

2016年1月10日 · Survivin is the smallest member of the inhibitor of apoptosis protein family, which has key roles in regulating cell division and inhibiting apoptosis by blocking caspase activation. Survivin is highly expressed in most human cancers, such as lung, pancreatic and breast cancers, relative to normal tissues.

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome.

2024年4月27日 · Survivin was initially identified as a member of the inhibitor apoptosis (IAP) protein family and has been shown to play a critical role in the regulation of apoptosis. More recent studies showed that survivin is a component of the chromosome passenger complex and acts as an essential mediator of mitotic progression.

2015年6月25日 · 摘要: Survivin是凋亡抑制蛋白 (inhibitor of apoptosis protein, IAP)家族的新成员, 参与调控细胞重要的生理病理过程, 具有抑制细胞凋亡、促进细胞增殖和肿瘤间质血管形成等作用。Survivin在正常终末分化组织中几乎检测不到, 而在大多数肿瘤组织中高表达, 其异常高表达与肿瘤的化疗耐药、肿瘤复发以及患者生存率密切相关。由于在肿瘤发生和发展中起重要作用, Survivin成为肿瘤基因诊治的理想靶点。 本文将就Survivin分子功能、Survivin与肿瘤的关系以 …

Survivin can serve as a universal tumor antigen because it is expressed in most human malignancies and has the potential to trigger immune effector responses. Therefore, blocking Survivin function by various immunotherapeutic or molecular approaches is emerging as a promising therapeutic strategy in cancer.

2024年8月1日 · Survivin, undetectable in adult tissues, is overexpressed in cancer and promotes its progression. Pro-survival cell signaling and Single Nucleotide Polymorphisms onset promote Survivin's role in cancer. Several Survivin inhibition strategies compromise tumor development.