IL-10 regulates adult neurogenesis by modulating ERK and STAT3 …
Our data showed that IL-10 activates ERK and promotes a pro-neural stage of Nestin+ progenitors of the adult SVZ, without affecting glial differentiation. However, when ERK1/2 …
Role of Akt and ERK signaling in the neurogenesis following brain ...
We found that intraperitoneal administration of vanadium compounds, a stimulator of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) …
Connexin 43-mediated neurovascular interactions regulate …
2023年4月25日 · The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSCs …
ERK Inhibition Rescues Defects in Fate Specification of
2012年8月17日 · Strikingly, these NF1-associated developmental defects are rescued by transient treatment with an MEK/ERK inhibitor during neonatal stages. This study reveals a critical role …
RAS/ERK inhibition rescues fate-specification defects of
2012年8月8日 · Strikingly, these NF1-associated developmental defects are rescued by transient treatment with an MEK/ERK pathway inhibitor during neonatal stages. These studies reveal a …
Chapter 26 Role of Akt and Erk Signaling in the ... - ScienceDirect
2009年1月1日 · We found that intraperitoneal administration of vanadium compounds, a stimulator of phosphatidylinositol 3‐kinase (PI3K)/Akt and extracellular signal‐regulated kinase …
Reelin Induces the Detachment of Postnatal Subventricular Zone …
2006年3月2日 · Our findings demonstrate that Reelin triggers ERK signaling in an SFK/mDab1- and PI3K-dependent manner and that ERK activation is required for Reelin-dependent …
IL-10 regulates adult neurogenesis by modulating ERK and STAT3 …
2015年2月25日 · The adult subventricular zone (SVZ) contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that interleukin-10 (IL-10) …
The regulatory mechanism of neurogenesis by IGF-1 in adult mice
These results demonstrate that IGF-1 upregulates the proliferation of NSCs by triggering MEK/ERK pathway signaling in the adult mice SGZ and SVZ. Meanwhile, IGF-1 also induces …
Extracellular Signal-regulated Kinase 5 (ERK5) Mediates Prolactin ...
2013年1月1日 · Results: Prolactin activates ERK5 in SVZ; suppression of ERK5 expression in vitro and erk5 deletion in vivo attenuates prolactin-induced adult neurogenesis. Conclusion: …