Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene. [5][6][7] It is a component of the synaptonemal complex formed between homologous chromosomes during the prophase of meiosis. [8] SYCP3 is also known as COR1.

2024年12月25日 · SYCP3 (Synaptonemal Complex Protein 3) is a Protein Coding gene. Diseases associated with SYCP3 include Spermatogenic Failure 4 and Male Infertility. Among its related pathways are Meiosis and Cell Cycle, Mitotic. An important paralog of this gene is FAM9A.

2020年6月26日 · In mammals, eight SC protein components have been identified so far: the proteins SYCP2 and SYCP3 of the lateral elements, SYCP1 of transverse filaments and the proteins SYCE1, SYCE2, SYCE3,...

2025年2月8日 · SCP3 is associated with lymphangiogenesis and provides insight into the SCP3-VEGF-C/VEGF-D axis based cancer therapy strategy. In the model, the reported compaction of chromosomal DNA caused by SYCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-like structure.

2001年4月16日 · SYCP3 localizes to the lateral elements of the synaptonemal complex and is essential for male meiosis. The genomic structure of SYCP3 consists of nine exons spanning approximately 14 kb. In mouse and rat, but not in hamster, the putative translation start of SYCP3 is present in the first exon.

Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

Here we show that human SYCP3 forms a highly-elongated helical tetramer of 20 nm length. N-terminal sequences extending from each end of the rod-like structure bind double-stranded DNA, enabling SYCP3 to link distant sites along the sister chromatid.

2014年6月20日 · A structural and biochemical study of human SYCP3 provides the first molecular model for the three-dimensional organisation that is imposed upon chromosomal DNA during meiosis and is essential for genetic exchange and fertility.

2024年12月24日 · SYCP3，全称synaptonemal complex protein 3，是一个位于人类染色体12q23.2的基因。它的主要功能是编码一种蛋白质，这种蛋白质在细胞的减数分裂过程中起着关键作用。减数分裂是生殖细胞形成过程中的一种特殊分裂方式，它确保了遗传信息的正确传递。 …

2019年10月31日 · Interaction between SYCP3 molecules is driven by the intrinsically disordered tails of the protein, with no contact between the helical cores, resulting in a flexible fibre assembly. We demonstrate that the SYCP3 fibre can engage in extensive interactions with DNA, indicative of an efficient mechanism for incorporation of DNA within the fibre.