2023年10月20日 · Transverse filament protein, SYCP1, spans the width of the SC and undergoes amino-terminal head-to-head self-assembly in vitro through a motif that is unusually highly …

2016年10月31日 · Yeast two-hybrid analysis reveals that SIX6OS1 interacts with the well-established protein synaptonemal complex central element 1 (SYCE1). Mice lacking SIX6OS1 …

2020年9月2日 · Synapsis is achieved through N-terminal head-to-head assembly of SYCP1 molecules, which are bound via their C termini to meiotic chromosomes. SYCP1 head-to-head …

2021年6月1日 · Here, we identify a protein complex that consists of germ-cell-specific zinc-finger protein ZFP541 and its interactor KCTD19 as the key transcriptional regulators in mouse …

2012年6月28日 · Spread pachytene nuclei were stained for SYCP3, MLH1 and CREST (to detect pericentromeric chromatin), and the positions of MLH1 foci were measured relative to …

2024年10月21日 · Prophase-I oocyte nuclei in early pachynema (A), early/mid pachynema (B), and mid pachynema (C) were immunostained for SYCP3, HEI10, and MLH1. Arrowheads …

Fbxw24-KO germ cells showed increased SYCP3 levels, delayed prophase progression, increased DSBs, and decreased crossover foci. Next, we found that FBXW24 directly binds …

2007年3月1日 · We investigated whether intact AEs or SCs are required for crossover interference in the mouse, using a mutant lacking AE protein SYCP3, which displays …

These images illustrate the association between late recombination sites (MLH1) and the protein components of the SC, SYCE3, and SYCP3, during the disassembly of the SYCE3 protein …

We have performed a detailed analysis of the location of proteins involved in synaptonemal complex assembly (SYCP3), recombination (RPA, RAD51 and MLH1) and sex chromosome …