Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue ...
Inhibition of Syk suppresses IgE- and IgG-associated FcR signal activation in various cell types; and suppresses experimental arthritis and skin and kidney disease in lupus-prone mice. We …
Syk Mediates BCR- and CD40-Signaling Intergration during B Cell ...
In this study, we show that CD40 ligation activates Syk-dependent pathway in B cells. CD40 costimulation promotes BCR-induced phosphorylation of Btk, B cell linker (BLNK), protein …
Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a
2017年1月20日 · MCh responsiveness was reduced to control levels in HDM-sensitized Syk del/del mice and in BALB/c and Syk flox/flox mice treated with GSK143. Both Syk del/del and …
Syk kinase is required for collaborative cytokine production …
Collaboration of Syk kinase and TLR/MyD88 pathways sustain IkB degradation and enhance NFkB nuclear translocation. TNF production from C57BL/6 wild-type and MyD88 –/– (A) or …
The Selective Syk Inhibitor P505-15 (PRT062607) Inhibits B Cell ...
2012年10月4日 · P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC 50 = 1 nM) with anti-SYK activity that is at …
The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative ...
2010年8月1日 · Recent findings identified ITK-SYK as the first recurrent translocation in 17% of unspecified PTCLs and showed the overexpression of SYK in more than 90% of PTCLs. Here, …
Targeting Syk-activated B cells in murine and human chronic graft ...
2015年6月25日 · In a murine model of multiorgan system, nonsclerodermatous disease with bronchiolitis obliterans where cGVHD is dependent on antibody and germinal center (GC) B …
Syk mediates BCR- and CD40-signaling integration during B cell ...
2011年5月1日 · In this study, we show that CD40 ligation activates Syk-dependent pathway in B cells. CD40 costimulation promotes BCR-induced phosphorylation of Btk, B cell linker (BLNK), …
Loss of spleen tyrosine kinase (Syk) activity impaired B cell ...
Spleen tyrosine kinase (SYK), a non-receptor protein tyrosine kinase, is reported to be related to cell survival after A/H (anoxia/hypoglycemia) insult. However, the role of...
Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a …
MCh responsiveness was reduced to control levels in HDM-sensitized Syk del/del mice and in BALB/c and Syk flox/flox mice treated with GSK143. Both Syk del/del and GSK143-treated …