淋巴细胞的信号传导（上） - 知乎 - 知乎专栏
Syk是BCR信号通路的关键激酶，含有两个SH2结构域，正好识别ITAM上的两个pTyr，能识别并磷酸化下游的多种蛋白，同时自身也能被磷酸化。 CD19/CD21/CD81复合物又被称为B细胞辅助 …
BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells
1999年1月1日 · BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)γ2 and JNK. The BCR-induced PLCγ2 activation, but not the …
BLNK mediates Syk-dependent Btk activation - PMC - National …
2001年2月2日 · We have demonstrated that BLNK mediates Syk-dependent Btk activation. In a reconstitution cell system, coexpression of BLNK allows Syk to phosphorylate Btk on its …
BLNK : a Central Linker Protein in B Cell Activation
1998年7月1日 · We report here the identification and characterization of a novel PTK substrate, BLNK, which is phosphorylated by Syk. Overexpression of wild-type BLNK results in enhanced …
BLNK: a central linker protein in B cell activation - PubMed
We describe here the identification of a novel B cell linker protein, termed BLNK, that interfaces the B cell receptor-associated Syk tyrosine kinase with PLCgamma, the Vav guanine …
Syk/BLNK/NF-κB signaling promotes pancreatic injury induced by ...
2024年2月1日 · In brief, Syk/BLNK/NF-κB signaling promotes pancreatic injury induced by tacrolimus and rapamycin has a potentially protective effect by down-regulating NF-κB. Further …
B and T Lymphocyte Attenuator Regulates B Cell Receptor …
2009年2月1日 · BLNK, a central adaptor molecule, is phosphorylated by Syk and recruits PLCγ2, bridging the kinase activity of Syk with downstream effector pathways (30, 31, 32). Both BLNK …
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in …
BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma 2 activation, but …
BLNK mediates Syk-dependent Btk activation - PNAS
2001年2月13日 · We have demonstrated that BLNK mediates Syk-dependent Btk activation. In a reconstitution cell system, coexpression of BLNK allows Syk to phosphorylate Btk on its …
BLNK: Immunity - Cell Press
1998年7月1日 · We report here the identification and characterization of a novel PTK substrate, BLNK, which is phosphorylated by Syk. Overexpression of wild-type BLNK results in enhanced …