TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK …
2004年7月15日 · Spleen tyrosine kinase (Syk), a nonreceptor protein kinase initially found to be expressed only in hemopoietic cells, has now been shown to be expressed in nonhemopoietic …
The SYK tyrosine kinase: a crucial player in diverse ... - Nature
2010年5月14日 · Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that has long been thought to exclusively mediate signalling by receptors of the adaptive immune...
MAPK级联调控细胞生长及其在免疫、炎症及癌症中作用的研究进 …
丝裂原活化蛋白激酶 (mitogen-activated protein kinase，MAPK)级联系统是真核生物细胞中高度保守的信号系统之一，参与诸多生物学过程的调控。 在细胞因子、神经递质及激素等不同信号 …
SYK regulates mTOR signaling in AML | Leukemia - Nature
2013年3月28日 · Evaluation of the collateral mitogen-activated protein kinase (MAPK) pathway revealed a heterogeneous response to SYK inhibition in AML with downregulation of MEK and …
SYK inhibition targets acute myeloid leukemia stem cells by …
2020年11月6日 · Spleen tyrosine kinase (SYK) is an important oncogene and signaling mediator activated by cell surface receptors crucial for acute myeloid leukemia (AML)...
TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK …
2004年7月15日 · We investigated whether TNF can activate Syk in hemopoietic and nonhemopoietic cells and whether Syk activation is involved in TNF-induced NF-κB, JNK, p38 …
SYK regulates mTOR signaling in AML - PubMed
Evaluation of the collateral mitogen-activated protein kinase (MAPK) pathway revealed a heterogeneous response to SYK inhibition in AML with downregulation of MEK and …
Resistance mechanisms to SYK inhibition in acute myeloid leukemia
The integration of functional genomic screening with the study of mechanisms of intrinsic and acquired resistance in model systems and human patients identified resistance to SYK …
BTN2A1 targeting reprograms M2-like macrophages and TAMs via SYK …
The study revealed that the engagement of BTN2A1 with our coated anti-BTN2A1 mAb triggered SYK and MAPK signaling in M-CSF-induced immunosuppressive macrophages, leading to …
Engagement of TLR and Dectin-1/Syk Signaling Is Required for ... - LWW
Zymosan binds and activates TLR2 and Dectin-1 receptors simultaneously to induce Notch target gene expression through Syk and TLR2-mediated MAPK activation which activates expression …
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