2022年10月17日 · In the studies presented here, we explored whether the intracellular signaling molecule, spleen tyrosine kinase (SYK), is involved in coordinating neuroprotective functions …

Using neuron-like SH-SY5Y cells, we demonstrate that SYK acts upstream of the mammalian target of rapamycin (mTOR) pathway and that pharmacological inhibition or knockdown of …

2023年11月3日 · SYK, an enzyme that catalyzes the phosphorylation of tyrosine, was initially cloned from pig spleen cDNA in 1991 . In previous studies, SYK was best considered to play a …

We found that the Syk inhibitors BAY61-3606 and P505-15 (at 1 and 10 μM, respectively) completely prevented the neuronal loss induced by LPS, which was microglia-dependent. Syk …

2021年8月27日 · The hippocampus level of SYK was significantly increased in 5XFAD Tg mice but not LM mice at postoperative 24 h. The immunostaining of SYK and G3BP1 showed that …

异甘草苷是一种酚类黄酮化合物，已被证明可以抑制 NLRP3 介导的细胞焦亡。 然而，异甘草苷是否可以通过刺激 miRNA-27a 来降低 NLRP3 介导的细胞焦亡，从而赋予抗抑郁活性仍然未知 …

2022年10月10日 · We found that 5-month-old 5xFAD SykΔMG mice had a ~1.5-fold increase in plaque-associated dystrophic neurites in the cortex compared with 5xFAD controls (Figures …

2021年12月24日 · Syk facilitates specific neutrophil functional responses to spinal cord injury including activation, cytokine expression, and cell death. Long-term neurologic deficits are …

2020年6月11日 · The Spleen Tyrosine Kinase (SYK) is known for its involvement in B-cell and T-cell signaling, modulating the peripheral immune response. We have previously shown that …

2023年3月15日 · We found that the Syk inhibitors BAY61-3606 and P505-15 (at 1 and 10 μM, respectively) completely prevented the neuronal loss induced by LPS, which was microglia …