Syk Inhibits the Activity of Protein Kinase A by Phosphorylating ...
2013年4月12日 · In this study, we identified and characterized PKAc as a substrate of Syk. Through phosphorylating Tyr-330, Syk strongly inhibits the activity of PKAc, attenuates the …
Structural and Biophysical Characterization of the Syk Activation ...
2013年1月23日 · Syk is an essential non-receptor tyrosine kinase in intracellular immunological signaling, and the control of Syk kinase function is considered as a valuable target for …
SYK kinase mediates brown fat differentiation and activation
2017年12月13日 · Deletion or inhibition of SYK, a kinase known for its essential roles in the immune system, blocks brown and white pre-adipocyte proliferation and differentiation in vitro, …
Syk inhibits the activity of protein kinase A by phosphorylating ...
2013年4月12日 · The phosphorylation of a downstream substrate of PKAc, cAMP-responsive element-binding protein (CREB), is inhibited in cells expressing Syk but can be rescued by a …
SYK spleen associated tyrosine kinase [ (human)] - National Center …
PKA is a novel substrate of Syk, and its phosphorylation on Tyr-330 inhibits its participation in downstream signaling pathways. Positive feedback enabled Syk to substantially compensate …
Differential Regulation of GPVI-Induced Btk and Syk Activation by …
PKA activation increased convulxin-induced Btk activation at Y551 but strongly suppressed Btk pS180 and Syk pS297. PP2A inhibition by okadaic acid only increased Syk pS297. Both …
The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β ...
2014年12月5日 · Our data show that PKA inactivation with KT5270 opposes the increased Ser-9 phosphorylation of GSK3β induced by Syk inhibition suggesting that Syk inhibition favors PKA …
Syk Inhibits the Activity of Protein Kinase A by Phosphorylating ...
The Syk protein-tyrosine kinase can have multiple effects on cancer cells, acting in some as a tumor suppressor by inhibiting motility and in others as a tumor promoter by enhancing …
Differential Regulation of GPVI-Induced Btk and Syk Activation by …
2023年4月24日 · Together, these results revealed in GPVI-stimulated platelets a transient Syk, Btk and PLCγ2 phosphorylation at multiple sites, which are differentially regulated by PKC, …
Syk Inhibits the Activity of Protein Kinase A by Phosphorylating ...
2013年2月27日 · PKA is a novel substrate of Syk, and its phosphorylation on Tyr-330 inhibits its participation in downstream signaling pathways and alters the expression of the CREB …