Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene (endogenous retrovirus group W envelope member 1). Syncytin-1 is a cell-cell fusion protein whose function is best characterized in placental development.

2000年2月17日 · Syncytin is the envelope protein of this endogenous retrovirus. DNA from nine species was examined by Southern blot, probing with syncytin-coding cDNA under stringent conditions. We identified...

合胞素（Syncytin）是一类由人俘获的逆转录病毒囊 膜蛋白 ，,表达基因是ERVWE1，与 胎盘 的 形态发生 中 细胞滋养层 到合胞滋养层的分化过程十分相关。Syncytin与人 免疫缺陷病毒 I型（ HIV-1）囊膜蛋白（Env）在结构上具有相似的特点，二者可能具有相似的 膜融合 ...

2000年2月17日 · This gene, encoding a protein that we have called syncytin, is the envelope gene of a recently identified human endogenous defective retrovirus, HERV-W. We find that the major sites of syncytin expression are placental syncytiotrophoblasts, multinucleated cells that originate from fetal trophoblasts.

In this review, we discuss the molecular structure and function of HERV ENV proteins, particularly syncytins, and their conventional roles in human development and diseases, and potential involvement in COVID-19 regarding the newly reported mental symptoms.

2023年10月19日 · Syncytin-2 is a human envelope protein with fusogenic activity, encoded by a gene from the HERV-FRD family—also known as ERVFRD-1. ERVFRD-1 has been functionally conserved in primates for more than 40 million years which suggests the strong effect of …

Syncytin is the envelope protein of a recently identified human endogenous defective retrovirus (HERV-W) that is expressed in the human in STB and, to a lesser amount, in testes but not other cell types.

The endogenous retroviral protein syncytin-1 and inflammatory marker CRP are both abnormally expressed in schizophrenia patients. CRP is one of the markers of bacterial infection generally. Less clear is whether virus or viral protein can trigger the activation of CRP.

Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found in particular in syncytiotrophoblast. After …

Syncytin-1 comprises two functional domains: the cell surface domain (SU) and the transmembrane domain (TM; Figure 2). SU binds with the host cell receptors, and TM promotes virus–cell or cell–cell fusion. Syncytin-1 plays a critical role in placental trophoblastic formation and is involved in the maternal immunosuppressive effect on the fetus.