STX4 基因位于16号染色体上，翻译出的蛋白质主要定位于细胞膜，参与了细胞内囊泡向细胞膜转运的过程，同时可能还参与了神经突触囊泡的对接过程。 参与介导了有相当的文献显示其该基因在人群中的变异性与肿瘤药耐药性、华法林维持时间等等存在关系。 ② Gene: SLC16A1 （solute carrier family 16 member 1）。 SLC16A1 基因编码的蛋白质属于 溶质载体家族 成员之一，主要定位于细胞膜和细胞连接处，能够促进一些单羧酸盐（如丙酮酸或者乳酸等）快速穿过细胞膜膜 …

2025年3月30日 · STX4 (Syntaxin 4) is a Protein Coding gene. Diseases associated with STX4 include Deafness, Autosomal Recessive 123 and Sensorineural Hearing Loss. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Vesicle-mediated transport.

Dlg5 is transported by cadherin-containing vesicles and binds to syntaxin 4, ensuring polarized membrane delivery of AJ proteins and maintenance of epithelial cell polarity. Syntaxin 4, as a t-SNARE protein, can regulate the fusion of transport vesicles and lateral membrane domains.

2017年1月6日 · We found that mouse ES cells cultured without GSK3β/MEK1/2 inhibitors (2i) spontaneously extrude syntaxin-4 at the cell surface and that artificial expression of cell surface syntaxin-4 induces...

2010年4月30日 · Here, we show that an exocytic domain adjacent to the postsynaptic density (PSD) enables fusion of large, AMPA receptor-containing recycling compartments during elevated synaptic activity.

2025年2月9日 · (MUNC18C = syntaxin binding protein MUNC18C; STX4 = syntaxin 4) Title: Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells. The analysis revealed three candidate genes GSK3B, PTPN1, STX4 that are differentially expressed in study subjects.

2021年10月18日 · Syntaxin 4 is a plasma membrane-localized SNARE protein that mediates the docking of transport vesicles. In human islets, syntaxin 4 regulates β-cell secretion and the preservation of β-cell...

Syntaxin 4 activation and insulin release in the absence of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis; Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons. Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.

The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling..

Syntaxin 4 (Stx4) is expressed highly in skeletal muscle and plays a critical role in insulin-stimulated glucose uptake by promoting translocation of glucose transporter 4 (GLUT4) to the cell surface.