A metal-free synthesis of primary aromatic amines from arylboronic acids affords structurally diverse primary arylamines in good chemical yields, including various halogenated primary anilines. The reaction is operationally simple, requires only a slight excess of aminating agent, proceeds under neutral or basic conditions, and can be scaled up ...

Synthesis of anilines ortho-andpara-substituted aryl halides can give rise to only 2- and 3-substituted arynes, respectively, meta-substituted aryl halides can give rise to either or both isomers. The direction of elimination for a meta-substituted halide is …

A research group from Bayer screened 80 ligands for the monoarylation of aniline with the activated aryl chloride para-chloronitrobenzene. Aniline was used as a neat reagent, CuBr and CuBr 2 were found to be the most effective copper sources and …

Consisting of a phenyl group (−C6H5) attached to an amino group (−NH2), aniline is the simplest aromatic amine. It is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis. Its main use is in the manufacture of precursors to polyurethane, dyes, and other industrial chemicals.

2016年10月31日 · Herein, we report an operationally simple arene C–H amination reaction that, in contrast to most literature precedent, affords directly the synthetically versatile primary aniline products without relying on protecting group manipulations. Inexpensive Fe(II)-sulfate serves as a convenient catalyst for the transformation.

Easy, efficient, and economic synthesis of anilines remains an important challenge in synthetic chemistry. In this study, a Ni(OAc)2-bipyridine complex is shown to readily catalyze the amination of...

2023年6月2日 · Immobilization of a nitroreductase enzyme permits continuous chemoenzymatic synthesis of anilines. Biocatalysis has become an integral part of the synthetic chemists’ toolbox over the last few decades.

2016年2月1日 · A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution (iSOAr) process. The products are obtained in good yields under mild and metal-free conditions.