Hybridization with Kreatech KMT2A/MLLT1 probe showing 2 green and 2 red signals on normal metaphase (left) and fusion signals on der(11) and der(19) chromosomes (right) (B) u2013 Courtesy Adriana Zamecnikova..

Patients with t(11;19)(q23;p13.1) all had leukemia of a myeloid lineage, mostly acute myeloid leukemia (AML), and were predominantly adult. In contrast patients with t(11;19)(q23;p13.3) had...

该例患者核型为t (11; 19) (q23; p13.1)，确诊为急性髓系白血病 (AML)-M 4c。 应用MA方案化疗后患者未获完全缓解。 t (11; 19) (q23; p13.1)是一类很独特的白血病亚型有关的易位，为少见的非随机染色体易位，其临床预后差。 引用本文: 谭丽, 刘芯, 曾金财, 等. 伴t (11；19) (q23; p13.1)恶性血液病的临床和实验室特征 [J] . 白血病·淋巴瘤, 2015, 24 (1) : 58-60. DOI: 10.3760/cma.j.issn.1009-9921.2015.01.017. 版权归中华医学会所有。 未经授权，不得转载、摘编本刊文章，不得使用本 …

Patients with t (11;19) (q23;p13.1) all had leukemia of a myeloid lineage, mostly acute myeloid leukemia (AML), and were predominantly adult. In contrast patients with t (11;19) (q23;p13.3) had malignancies of both myeloid and lymphoid lineage and were mainly infants less than 1 year old.

1997年12月1日 · Acute myeloid leukemia with t (11;19) (q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report. Changing the frequency and spectra of chromosomal aberrations in Korean …

Mature T-Cell And NK-Cell Lymphoma/Leukemia + t(11;19)(q23; p13.1) is an inclusion criterion in 2 clinical trials for mature T-cell and NK-cell lymphoma/leukemia, of which 0 are open and 2 are closed.

1996年6月1日 · We therefore used reverse transcriptase-polymerase chain reaction (RT-PCR) assays to analyze 26 cases of childhood acute leukemia containing t (11; 19) to determine the frequencies of ENL and ELL involvement. All 17 cases of acute lymphoblastic leukemia (ALL) had MLL/ENL fusion transcripts.

2007年7月1日 · We analyzed the presence of a balanced t(11;19)(q21; p12~p13.11) and the MECT1-MAML2 fusion transcript in a 9-year-old girl with mucoepidermoid lung carcinoma using conventional cytogenetics, fluorescence in-situ hybridization, spectral karyotyping, high-resolution multicolor banding, and reverse transcriptase–polymerase chain reaction.

We report the case of a 10-year-old female with acute myeloid leukemia (AML) FAB M0 carrying a novel t(11;19)(q23;p13.1) MLL-ELL variant, in which intron 8 of MLL is fused to exon 6 of ELL. Complete remission, judged by morphology and cytogenetic analysis, was achieved after the conventional chemoth …

Here we identify a new mechanism for disrupting Notch signaling in human tumorigenesis, characterized by altered function of a new ortholog of the Drosophila melanogaster Notch co-activator molecule Mastermind. We cloned the t(11;19) translocation that underlies the most common type of human malignant salivary gland tumor.