1995年6月15日 · We have characterized the recurrent t (12;21) (p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1, that have previously been described in chromosomal translocations specific for myeloid malignancies.

The t(12;21) which disrupts hematopoietic differentiation and proliferation, and can be present as a sole abnormality or within the context of a complex karyotype characterized by three or more chromosomal abnormalities. The prognosis of t(12;21) within a complex karyotype is …

1997年8月1日 · Precision medicine in acute lymphoblastic leukemia. An intact gut microbiome protects genetically predisposed mice against leukemia. Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913.

t(12；21)(p13；q22)易位可见于15%～35%的儿童B细胞ALL，其中12p13区的TEL和21q22区的AML1形成融合基因是最常见的畸变 ，在成人和幼儿患者中很罕见，主要见于儿童。

1995年6月15日 · We have characterized the recurrent t (12;21) (p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1, that have previously been described in chromosomal translocations specific for myeloid malignancies.

The t(12;21) translocation, which generates the TEL-AML1 (ETV6-RUNX1) fusion gene, is the most common structural chromosome change in childhood cancer and is exclusively associated with the common B cell precursor subset of acute lymphoblastic leukemia (ALL).

The t(12;21)(p13;q22) is identified by routine cytogenetics in less than 0.05% of pediatric acute lymphoblastic leukemia (ALL) patients. This translocation encodes a TEL/AML-1 chimeric product comprising the helix-loop-helix domain of TEL, a member of …

The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL-AML1, is transcribed from the der(21) and e …

2005年10月1日 · The t(12;21)(p13;q22) translocation, which involves the ETV6 gene (previously TEL) located on 12p13 and the RUNX1 gene (previously AML1) on 21q22, is found in 20–30% of children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) [1], [2], [3], [4] and in 3–4% of adult cases of ALL [5], [6], [7].

2009年7月1日 · The translocation t (12;21) (p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively.