The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells).

2000年10月1日 · Evidence exists for the involvement of the most primitive and quiescent hematopoietic stem cell compartiment (CD34+/CD38-, Thy1+): t(9;22) is found in myeloid progenitor and in B-lymphocytes progenitors, but, involvement of the T …

t(9;22)(q34;q11) 其含义是：t(9, 22)代表9号染色体和22号染色体各自断裂，然后断裂下来的部分交换位置，这被称为染色体易位。 而(q34; q11)则标记了两条染色体各自的断裂位置：9号染色体长臂的第3区第4带，22号染色体长臂第1区第1带。

t(9;22)(q34;q11)怎么读或者说表示什么它是指PH染色体，即费城染色体t代表易位，cq代表染色体长臂这个染色体表达方式是在说，费城染色体是由于9号染色体的长臂3区4带以下断裂，同时22号染色体的长臂1区1带以下也断裂

而t（9;22）（q34;q11）是慢性髓性白血病（CML）的标志性染色体异常，在成人急性淋巴细胞白血病（ALL）中发生率为30%左右，在AML中少有发生。此两种异常共存比较少见，且多为CML急变，即t（9;22）（q34;q11）为原发性异常，t（8;21）（q22;q22）为继发性异常。

2017年5月12日 · At 3 years, for children with a classic translocation, children with ACAs, and children with a variant t (9;22) translocation who were treated with imatinib as frontline therapy, the probability of progression-free survival (PFS) was 95% (95% confidence interval [CI], 91%-97%), 100%, and 75% (95% CI, 13%-96%), respectively, and the probability o...

t(9; 22)(q34; q11.2)/ BCR-ABL是慢性粒细胞白血病（CML）的特征性变异，除此以外的其他染色体异常通常赋予不良预后，并且在CML的急变期（CML-BP）中常见。inv(16)，是一种急性髓细胞白血病（AML）相关的染色体异…

Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.

2016年5月27日 · The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stability.

2009年7月28日 · The Philadelphia (Ph 1) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various ...