2021年9月3日 · 下图是3个典型的大颗粒t淋巴细胞白血病（t-lgll）病例，用于与t-cus进行对比，其特点是在骨髓（上、下）或外周血（中）标本有类似的克隆性cd8阳性t细胞群（红色事件），其trbc1呈阴性（上）、弱阳（中）或阳性（下）。

2020年5月13日 · In routine laboratory practice, T-cell clones of uncertain significance (T-CUS) were detected in 42 of 159 (26%) patients without T-cell malignancy, and in 3 of 24 (13%) healthy...

TCR-Vβ repertoire analysis confirmed the clonality of T-CUS, and identified additional clonotypic CD8-positive subsets when combined with TRBC1 analysis. We hereby report the phenotypic features and incidence of clonal T-cell subsets in patients with no demonstrable T-cell neoplasia, providing a framework for the differential interpretation of ...

2025年1月1日 · T-cell clones of uncertain significance (T-CUS) exhibit molecular and immunophenotypic features closely resembling those of T-cell large granular lymphocytic leukemia (T-LGLL). However, individuals harboring these rogue clones lack any clinical or laboratory features supporting a diagnosis of a T-cell malignancy.1-3

2023年7月1日 · T-CUS shows immunophenotypic features closely resembling those of T-cell large granular lymphocytic leukaemia but the individuals are devoid of clinical or laboratory features, which would support a diagnosis of T-cell malignancy, in particular, bone marrow invasion, associated diseases, cytopenias, and related symptoms.

Results: T-CUS was identified in 152 samples from 92 patients. The majority (76%) were CD8+ and demonstrated an immunophenotype resembling large granular lymphocytes. Eighteen patients had serial samples for longitudinal analysis (9.8 months median follow-up). Clone size was stable in 66%, whilst the remainder reduced or disappeared.

在常规实验室实践中，在 159 名无 T 细胞恶性肿瘤患者中的 42 名 (26%) 和 24 名 (13%) 健康供体中的 3 名患者中检测到意义不明的 T 细胞克隆 (T-CUS)。 它们的表型（CD8+/CD4-：78%，CD4-/CD8-：12%，CD4+/CD8+：9%，或 CD4+/CD8-：2%）与 26 例 T 细胞大颗粒淋巴细胞白血病的表型非常相似 (T-LGLL) 进行了类似的研究，除了克隆大小小得多 (p < 0.0001)，CD2 和 CD7 稍亮，和稍微暗淡的 CD3 表达 (p < 0.05)。 T-CUS 与年龄、性别、合并症或外周血细胞计数无关。

Benign clonal T-cell expansions, however, are commonly found in patients without identifiable disease, a condition referred to as T-cell clones of uncertain significance (T-CUS). In practice, T-cell clonality testing is performed for a range of reasons and results are often challenging to interpret given the overlap between benign and malignant ...

2000年1月1日 · T-CUS are a potential precursor of T-cell malignancies, mainly T-cell large granular lymphocytic leukaemia. The precise incidence of T-CUS is still being refined. Due to the availability of increasingly sensitive laboratory assays, it is envisaged that T-CUS will be more frequently intercepted.

We compared the differential expression of 15 markers in PTCL (Peripheral T-cell lymphoma) subtypes and T-CUS (T-cell clones of uncertain significance), and summarized the specific immunophenotype profiles of each subtype and its impact on prognosis. PD-1 and CD10 are diagnostic markers for AITL (angioimmunoblastic T-cell lymphoma).