Antigen-presenting cells display three types of protein molecules on their surface that have a role in activating a T cell to become an effector cell: (1) MHC proteins, which present foreign antigen to the T cell receptor, (2) costimulatory proteins, which bind to complementary receptors on the T cell surface, and (3) cell-cell adhesion ...

The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.

2021年3月22日 · Macrophages are central regulators in T cell activation and are involved in each step including initiating the series of events leading to T cell activation. Macrophages identify and present foreign antigens in classes I and II major histocompatibility complexes (MHC) to T cells, which recognize the MHC-antigen complex through their T cell ...

2004年4月1日 · The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4 + T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.

CD4 + lymphocytes, also known as T-helper lymphocytes, exert their immunomodulatory function after antigen recognition by MHC-II binding, while the cytotoxic CD8 + subset are responsible for MHC-I-mediated binding and cytolysis of virally infected or tumor endogen cells. After antigen recognition, T-helper lymphocytes can differentiate into Th1 ...

2022年12月6日 · Zinkernagel and Doherty used lymphocytic choriomeningitis virus (LCMV) and developed a method of obtaining cytotoxic T lymphocytes (CTLs) from the cerebrospinal fluid of infected mice.

2023年8月31日 · MHC molecules enable T-lymphocytes to recognize epitopes and discriminate self from non-self. T-cell receptors (TCRs) of T-lymphocytes can only recognize epitopes - typically short chains of amino acids called peptides - after they are bound to MHC molecules. MHC-I presents epitopes to T8-lymphocytes; MHC-II presents epitopes to T4-lymphocytes.

The model presented relates the class of MHC molecule recognized with the activity of T lymphocytes. This occurs by postulating that the function of MHC molecules is to present determinants to differentiation directing (D) receptors on T lymphocytes.

2001年1月12日 · In the last four years, the atomic structures of more than a half-dozen of the intercellular recognition complexes, formed by αβT cell receptors (αβTCR) on cytotoxic T lymphocytes (CTL) or T helper cells and MHC/peptide complexes on antigen presenting cells, have been visualized by X-ray crystallography (Figure 1A).

2023年6月19日 · T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and mainly generates CD4+ and CD8+ T cell...