Talimogene laherparepvec is a genetically engineered herpes virus (an oncolytic herpes virus). Two genes were removed – one that shuts down an individual cell's defenses, and another that helps the virus evade the immune system – and a gene for human GM-CSF was added.

Talimogene laherperepvec (T-VEC) is an injectable modified oncolytic herpes virus being developed for intratumoral injection, that produces granulocyte-macrophage colony-stimulating factor (GM-CSF) and enhances local and systemic antitumor immune responses.

T-VEC is an oncolytic virus therapy, a treatment that uses a virus to infect and kill cancer cells while avoiding normal, healthy cells. T-VEC is made from a genetically modified herpes virus, commonly known as the cold sore virus.

2015年10月29日 · t-vec是一种经过基因修饰的1型单纯疱疹病毒（hsv-1），它可以在肿瘤细胞内复制并表达免疫激活蛋白粒细胞-巨噬细胞集落刺激因子（gm-csf）。 将其直接注射到黑色素瘤病灶中可造成肿瘤细胞的溶解，从而使肿瘤细胞破裂，并释放出肿瘤源性抗原和GM-CSF，加速抗 ...

2015年11月25日 · The FDA has approved the first oncolytic virus therapy, talimogene laherparepvec (T-VEC). The drug was approved for the treatment of metastatic melanoma that cannot be removed surgically.

Talimogene laherparepvec (T-VEC) is an immunotherapy treatment for melanoma skin cancer. Find out how it works, when you have it, side effects and other important information.

As the first OV approved by the Food and Drug Administration (FDA) for melanoma treatment, talimogene laherparepvec (T-VEC), a genetically modified herpes simplex virus (HSV), has shown promising therapeutic effects in the treatment of advanced melanoma, both as a monotherapy or in combination with other immunotherapies, such as the immune ...

Talimogene laherperepvec (T-VEC) is an injectable modified oncolytic herpes virus being developed for the treatment of advanced melanoma. Pre-clinical studies have shown that T-VEC preferentially infects melanoma cells and exerts antitumor activity through directly mediating cell death and by augmenting local and even distant immune responses.

2023年8月14日 · t-vec等疗法被认为是治疗黑色素瘤的理想方法，因为：（1）转移灶的存在表明黑色素瘤细胞同时扩散到了真皮淋巴管，使手术切除变得困难；（2）黑色素瘤的转移灶会优先扩散到皮肤，使其成为通过区域内疗法进行靶向治疗的最佳选择。

2015年6月16日 · T-VEC is an oncolytic viral therapy comprising attenuated herpes simplex virus type 1 that has been modified to mediate a two-pronged attack on tumours: selective lysis of cancer cells after...