2023年6月19日 · Abnormal T-cell immunity can initiate and promote the pathogenesis of autoimmune diseases. In this review, we summarize the current understanding of T cell development, CD4 + and CD8 + T...

The developing progenitors within the thymus, also known as thymocytes, undergo a series of maturation steps that can be identified based on the expression of different cell surface markers. The majority of cells in the thymus give rise to αβ T cells, however approximately 5% bear the γδ T cell receptor (TCR).

2020年7月30日 · T-cell maturation involves the re-arrangement of the germ-line TCR genes and the expression of various membrane markers. In thymus, the developing T cells are termed as thymocytes.

2004年1月1日 · Interactions between Notch receptor-expressing thymocytes 78 and thymic stromal cells that express Notch ligands 61, 62 induce a complex programme of T-cell maturation in the thymus, which...

2022年4月10日 · Memory T cells are a class of T cells that are long-lived and can quickly expand into a large number of effector T cells when re-exposed to the antigen that activated them in …

Double-positive cells (CD4+/CD8+) that are positively selected on MHC class II molecules will eventually become CD4+ helper T cells, while cells positively selected on MHC class I molecules mature into CD8+ cytotoxic T cells.

2025年3月17日 · Explore the key stages of T cell maturation, from early development in the thymus to functional specialization, shaping immune response and self-tolerance. T cells are a crucial part of the adaptive immune system, responsible for …

T cells arise from common lymphoid progenitors (CLPs) that differentiate from hematopoietic stem cells in the bone marrow. CLPs then traffic to the thymus, where they undergo thymopoiesis through a number of selection steps, resulting in mature single positive naive CD4 helper or CD8 cytotoxic T cells.

2002年5月1日 · Immature thymocytes express both CD4 and CD8, but mature functional T cells express the co-receptor molecule that has an MHC-class specificity that matches that of the cell's TCR.

T cell development occurs in the thymus in both mice and humans. Upon entry into the thymus, bone marrow-derived blood-borne progenitors receive instructive signals, including Notch signaling, to eliminate their potential to develop into alternative immune lineages while committing to the T cell fate.