2022年12月6日 · HPAP-T2D is designed to define the molecular pathogenesis of islet dysfunction by procuring human pancreas and curating de-identified clinical information from donors with T2D, generating detailed datasets of physiological, morphological, transcriptomic, epigenomic, and genomic information and making the data immediately available to the ...

Multiple human studies of T2D have shown that targeting islet inflammation has the potential to be an effective therapeutic strategy. In this Review we provide an overview of the cellular and molecular mechanisms by which islet inflammation develops and causes β cell dysfunction.

2024年10月8日 · Endoplasmic reticulum (ER) and inflammatory stress responses contribute to islet dysfunction in type 2 diabetes (T2D). Comprehensive genomic understanding of these human islet stress responses and whether T2D-associated genetic variants modulate them is …

T2D is associated with a chronic low-grade inflammation that manifests in several metabolic organs including the pancreatic islets. Growing evidence suggests that components of the innate immune system, and especially macrophages, play a crucial role in regulating islet homeostasis.

2021年6月17日 · Type 1 and type 2 diabetes (T1D and T2D) converge in the later stages of disease on dysfunction of pancreatic islet β-cells and a progressive loss of insulin production. Seminal studies in the...

2019年4月15日 · Type 2 diabetes (T2D) is a chronic progressive disease associated with obesity and insulin resistance. The onset of T2D is mainly determined by the progressive failure of the pancreatic islet β-cells to secrete sufficient levels of insulin to maintain normoglycemia [1, 2].

2022年1月20日 · During obesity-induced type 2 diabetes (T2D), islet β cells become dysfunctional and inadequate insulin secretion no longer ensures glycemic control. T2D is associated with a chronic low-grade inflammation that manifests in several metabolic organs including the pancreatic islets.

2019年5月7日 · At IGF2BP2, a fine-mapped T2D variant reduces islet enhancer activity and IGF2BP2 expression, and conditional inactivation of IGF2BP2 in mouse islets impairs glucose-stimulated insulin...

2017年1月3日 · Multiple human studies of T2D have shown that targeting islet inflammation has the potential to be an effective therapeutic strategy. In this Review we provide an overview of the cellular and molecular mechanisms by which islet inflammation develops and causes β …

Islet β cell failure in T2D occurs when islets are unable to sustain β cell compensation for insulin resistance. The failure is progressive, particularly after hyperglycemia is established, which leads to poorly functioning, de-differentiated β cells and loss of β cell mass from apoptosis (Figure 3 ).